{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"25"}]}],"title":"Revlimid"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1.3"}]}],"title":"VELCADE"},{"categories":[{"measurements":[{"groupId":"OG000","value":"20"}]}],"title":"Dexamethasone"},{"categories":[{"measurements":[{"groupId":"OG000","value":"30"}]}],"title":"Doxil"}],"denoms":[{"counts":[{"groupId":"OG000","value":"42"}],"units":"Participants"}],"description":"Dose Level 1:\n\n15 mg Revlimid daily on days 1-14 followed by 7-day rest every 21 days 1.3 mg/m2 Velcade daily on days 1, 4, 8 and 11 20 mg dexamethasone daily on Days 1, 2, 4, 5, 8, 9, 11, 12\\* and 20 mg/m2 Doxil daily on day 4\n\nDose Level 2:\n\n20 mg Revlimid daily on days 1-14 followed by 7-day rest every 21 days 1.3 mg/m2 Velcade daily on days 1, 4, 8 and 11 20 mg dexamethasone daily on Days 1, 2, 4, 5, 8, 9, 11, 12\\* and 20 mg/m2 Doxil daily on day 4\n\nDose Level 3:\n\n25 mg Revlimid daily on days 1-14 followed by 7-day rest every 21 days 1.3 mg/m2 Velcade daily on days 1, 4, 8 and 11 20 mg dexamethasone daily on Days 1, 2, 4, 5, 8, 9, 11, 12\\* and 20 mg/m2 Doxil daily on day 4\n\nDose Level 4:\n\n25 mg Revlimid daily on days 1-14 followed by 7-day rest every 21 days 1.3 mg/m2 Velcade daily on days 1, 4, 8 and 11 20 mg dexamethasone daily on Days 1, 2, 4, 5, 8, 9, 11, 12\\* and 30 mg/m2 Doxil daily on day 4","groups":[{"description":"Patients will be treated with Velcade at 1.3 mg/m2 on days 1, 4, 8, and 11, Doxil at indicated doses on day 4, Dexamethasone at 20 mg orally on days of Velcade and the day after for all dose levels, and Revlimid at indicated doses on days 1-14 in 3-week cycles for 4-8 cycles.","id":"OG000","title":"Combination Drug Therapy"}],"paramType":"NUMBER","populationDescription":"A total of 74 patients were enrolled in this phase 1/2 study: 42 in phase 1.","reportingStatus":"POSTED","timeFrame":"1 month post treatment","title":"Maximum Tolerated Dose (MTD) of Combination Therapy With VELCADE, Dexamethasone, and Doxil, (RVDD)","type":"PRIMARY","unitOfMeasure":"mg"}