{"groups":[{"description":"See Detailed Description\n\nAsparaginase: Given IT\n\nCyclophosphamide: Given IV\n\nCytarabine: Given IT or IV\n\nDasatinib: Given PO\n\nDaunorubicin Hydrochloride: Given IV\n\nDexamethasone: Given IV or PO\n\nEtoposide: Given IV\n\nFilgrastim: Given IV or SC\n\nHydrocortisone Sodium Succinate: Given IT\n\nIfosfamide: Given IV\n\nLaboratory Biomarker Analysis: Correlative studies\n\nLeucovorin Calcium: Given IV or PO\n\nMercaptopurine: Given PO\n\nMethotrexate: Given IT, PO, or IV\n\nMethylprednisolone: Given IV\n\nPegaspargase: Given IM\n\nPrednisone: Given PO or IV\n\nRadiation Therapy: Some patients undergo cranial RT\n\nVincristine Sulfate: Given IV","id":"FG000","title":"Treatment Induction (Enzyme Inhibitor Therapy & Chemotherapy)"},{"description":"Based on Minimal Residual Disease, less than 1%.","id":"FG001","title":"Standard-risk"},{"description":"Based on Minimal Residual Disease, great than or equal to 1%.","id":"FG002","title":"High-risk"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"}],"type":"Did not meet eligibility criteria"},{"reasons":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"}],"type":"Bone Marrow Transplant"},{"reasons":[{"groupId":"FG000","numSubjects":"1"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"}],"type":"Physician Decision"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"63"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"57"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"6"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"}],"type":"NOT COMPLETED"}],"title":"Induction Period"},{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"1"},{"groupId":"FG002","numSubjects":"0"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"2"},{"groupId":"FG002","numSubjects":"1"}],"type":"Physician Decision"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"9"},{"groupId":"FG002","numSubjects":"7"}],"type":"Bone marrow transplant"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"2"},{"groupId":"FG002","numSubjects":"0"}],"type":"Disease progression or relapse"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"1"},{"groupId":"FG002","numSubjects":"0"}],"type":"Development of second malignant neoplasm"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"48"},{"groupId":"FG002","numSubjects":"9"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"33"},{"groupId":"FG002","numSubjects":"1"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"15"},{"groupId":"FG002","numSubjects":"8"}],"type":"NOT COMPLETED"}],"title":"Risk Stratification Period"}]}