{"eventGroups":[{"description":"Bortezomib 1.3 milligram (mg) per meter\\^2 (m\\^2) bolus (a large amount) intravenous (into the vein) injection will be administered once daily on Days 1, 4, 8 and 11 of each 21-day cycle with addition of Dexamethasone 20 mg per day administered orally, once daily on Days 1 and 2, Days 4 and 5, Days 8 and 9 and Days 11 and 12 of each 21-day cycle as per Investigator's discretion for those participants who experience disease progression after treatment completion up to Cycle 2 or have no change from Baseline after completion of at least 4 cycles. The treatment will be given up to 8 cycles (24 weeks).","id":"EG000","otherNumAffected":9,"otherNumAtRisk":10,"seriousNumAffected":4,"seriousNumAtRisk":10,"title":"Bortezomib and Dexamethasone"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypotension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Orthostatic hypotension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypertension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Dyspnoea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Cough"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Mood altered"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Confusional state"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Peripheral sensory neuropathy"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Neuropathy peripheral"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Neuralgia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Muscular weakness"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Hypokalaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypocalcaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Anorexia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"International normalised ratio increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":10}],"term":"Blood creatinine increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Blood albumin decreased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Contusion"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Herpes zoster"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Bacteraemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Fatigue"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Asthenia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Vomiting"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Diarrhoea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Constipation"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Abdominal pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":10}],"term":"Thrombocytopenia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Lymphopenia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Leukopenia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10}],"term":"Anaemia"}],"seriousEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Pneumonia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Diarrhoea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Renal impairment"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Hypertension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Muscle weakness"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Depressed level of consciousness"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Aphasia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Speech disorder"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Confusion state"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Gastrointestinal haemorrhage"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10}],"term":"Dehydration"}],"timeFrame":"Day 1 up to 30 days after last dose of study medication"}