{"analyses":[{"groupDescription":"Comparison of baseline estradiol between LC/MS and RIA","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":">0.05","pValueComment":"Significant at p\\<0.05","statisticalMethod":"t-test, 2 sided","testedNonInferiority":false},{"groupDescription":"Comparison of week 4 estradiol between LC/MS and RIA","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER","pValue":">0.05","pValueComment":"singificant at p\\<0.05","statisticalMethod":"t-test, 2 sided","testedNonInferiority":false}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.5","value":"17.7"},{"groupId":"OG001","spread":"44.1","value":"17.9"}]}],"title":"Baseline E2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.0","value":"7.8"},{"groupId":"OG001","spread":"13.4","value":"2.9"}]}],"title":"4-week E2"}],"denoms":[{"counts":[{"groupId":"OG000","value":"63"},{"groupId":"OG001","value":"63"}],"units":"Participants"}],"description":"Serum estradiol assays sent to the UCSF clinical laboratory are sent out to Quest Diagnostics, which uses LC/MS for their ultra-sensitive estradiol assay. Samples were also sent to a specialized research lab in England which has developed an ultrasensitive assay using radioimmunoassay (RIA) after ether extraction (sensitivity limit of 3pmol/l) to quantify low levels of estradiol found in post-menopausal women","dispersionType":"Standard Deviation","groups":[{"description":"A commercially available ultrasensitive E2 level was measured at baseline and 4 weeks (Quest Diagnostics, liquid chromatography tandem mass spectrometry (LC/MS, PM range \\<10 pg/ml)","id":"OG000","title":"E2 by LC/MS"},{"description":"Additional measurement of baseline and week 4 E2 by RIA","id":"OG001","title":"E2 by RIA"}],"paramType":"MEAN","populationDescription":"Patients from both study arms arms with matched pairs of baseline and week 4 E2 performed by both commercial and research labs","reportingStatus":"POSTED","timeFrame":"baseline, 4 weeks","title":"Matched E2 by Commercial and Research (RIA) Analyses","type":"SECONDARY","unitOfMeasure":"pg/ml"}