{"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}],"units":"Participants"}],"description":"PK modeling, either compartmental or noncompartmental-based, was used to describe serum concentrations. Standard PK parameters estimated include: area-under-the-concentration-time curve (AUC), maximum-observed concentration (Cmax), time-to-reach maximum concentration (Tmax), total body clearance (Cl), volume of distribution (Vd), and elimination half-life (t1/2).","groups":[{"description":"Intravenous (IV) infusions of natalizumab 300 mg once every 28 days for 6 months.","id":"OG000","title":"Natalizumab 300 mg"},{"description":"Intravenous (IV) infusions of natalizumab 450 mg once every 28 days for 6 months.","id":"OG001","title":"Natalizumab 450 mg"}],"populationDescription":"PK analysis was not performed because the study was terminated early.","reportingStatus":"POSTED","timeFrame":"Cycles 1 and 6: Day 1 (before infusion and 0.25, 2, 6 and 24 hours after infusion), Days 8, 15, 22. Cycles 2-5: Day 1 (before infusion and 0.25 hour after infusion)","title":"Pharmacokinetic (PK) Profile Of Natalizumab","type":"SECONDARY"}