{"analyses":[{"groupIds":["OG000"],"nonInferiorityComment":"The association between response and Ktrans at Week 10 was evaluated.","nonInferiorityType":"OTHER","pValue":"0.0863","statisticalMethod":"Logistic Regression"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.04","value":"0.13"},{"groupId":"OG001","spread":"0.07","value":"0.15"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"Baseline"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.05","value":"0.11"},{"groupId":"OG001","spread":"0.03","value":"0.14"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"title":"Day -2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.06","value":"0.12"},{"groupId":"OG001","spread":"0.04","value":"0.16"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"title":"Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.06","value":"0.14"},{"groupId":"OG001","spread":"0.04","value":"0.16"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"Day 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.04","value":"0.08"},{"groupId":"OG001","spread":"0.05","value":"0.10"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"28"},{"groupId":"OG001","value":"11"}],"units":"Participants"}],"title":"Week 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.05","value":"0.07"},{"groupId":"OG001","spread":"0.03","value":"0.07"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"11"}],"units":"Participants"}],"title":"Week 10"}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"11"}],"units":"Participants"}],"description":"The volume transfer constant (Ktrans) was used to evaluate clinical outcomes. The average for the distribution across the whole region of interest (ROI) was calculated as a summary measure for each data set.","dispersionType":"Standard Deviation","groups":[{"description":"Stratum A participants had primary tumors potentially resectable by aggressive surgery, such as limb-salvage surgery or amputation, and no evidence of metastasis.","id":"OG000","title":"A: Localized Resectable Disease"},{"description":"Stratum C participants had metastatic tumors.","id":"OG001","title":"C: Metastatic Tumors"}],"paramType":"MEAN","populationDescription":"The number analyzed at each time point differed due to missing observations at some of the time points","reportingStatus":"POSTED","timeFrame":"Baseline through Week 10","title":"Mean Ktrans","type":"SECONDARY","unitOfMeasure":"min(-1)"}