{"analyses":[{"ciLowerLimit":"0.82","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"2.35","estimateComment":"Raw proportions were used to estimate the verified cessation rate in each group and corresponding odds ratio along with its 95% confidence interval .","groupDescription":"Based on our previous studies, sample size was determined a priori assuming a two-sided x2 test with a type I error rate of .05, a power of 80%, and a cotinine-verified abstinence rate of 15% in the placebo group and 25% in the bupropion SR group at week 26, with the assumption that those lost to follow-up would be imputed as smokers.","groupIds":["OG000","OG001"],"nonInferiorityComment":"The x2 test was used to determine whether there was a difference between treatment groups (bupropion SR vs placebo) in verified 7-day point prevalence abstinence at week 26, imputing the missing participants as smokers.","nonInferiorityType":"SUPERIORITY","pValue":".23","pValueComment":"All tests of statistical significance were two-sided, and all P values less than .05 were considered statistically significant.","paramType":"Odds Ratio (OR)","paramValue":"1.39","statisticalMethod":"t-test, 2 sided"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"36"},{"groupId":"OG001","value":"27"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"270"},{"groupId":"OG001","value":"270"}],"units":"Participants"}],"description":"Salivary cotinine-verified smoking abstinence at 6 months. A cut point of 15 ng/ml was used to differentiate smokers from nonsmokers.","groups":[{"description":"270 African American adults received bupropion (150mg bid) for 7 weeks in addition to health education counseling.","id":"OG000","title":"Bupropion Arm"},{"description":"270 African American adults received placebo for 7 weeks in addition to health education counseling.","id":"OG001","title":"Placebo Arm"}],"paramType":"COUNT_OF_PARTICIPANTS","reportingStatus":"POSTED","timeFrame":"6 months","title":"Number of Participants With Salivary Cotinine-verified Smoking Abstinence at 6 Months","type":"PRIMARY","unitOfMeasure":"Participants"}