{"groups":[{"description":"Patients receive dexamethasone PO QD on days 1, 8, 15, and 22 and lenalidomide PO QD on days 1-21. Treatment repeats every 28 days for 6 courses in the absence of disease progression or unacceptable toxicity.\n\nDexamethasone: Given PO\n\nLaboratory Biomarker Analysis: Optional correlative studies\n\nLenalidomide: Given PO","id":"FG000","title":"Arm I (Dexamethasone and Lenalidomide)"},{"description":"Patients receive dexamethasone PO QD on days 1, 2, 4, 5, 8, 9, 11, and 12; lenalidomide PO QD on days 1-14; and bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11. Treatment repeats every 21 days for 8 courses in the absence of disease progression or unacceptable toxicity.\n\nBortezomib: Given IV\n\nDexamethasone: Given PO\n\nLaboratory Biomarker Analysis: Optional correlative studies\n\nLenalidomide: Given PO","id":"FG001","title":"Arm II (Dexamethasone, Lenalidomide, Bortezomib)"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"31"},{"groupId":"FG001","numSubjects":"21"}],"type":"Ineligible"},{"reasons":[{"groupId":"FG000","numSubjects":"1"},{"groupId":"FG001","numSubjects":"0"}],"type":"Withdrew Consent prior to therapy start"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"1"}],"type":"Invalid Consent"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"261"},{"groupId":"FG001","numSubjects":"264"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"229"},{"groupId":"FG001","numSubjects":"242"}],"comment":"All patients who were consented and did not withdraw consent prior to treatment are \"Analyzable\".","type":"Eligible and Analyzable"},{"achievements":[{"groupId":"FG000","numSubjects":"229"},{"groupId":"FG001","numSubjects":"242"}],"comment":"\"Completed\" does not apply to this study period.","type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"32"},{"groupId":"FG001","numSubjects":"22"}],"type":"NOT COMPLETED"}],"title":"Randomization & Eligibility"},{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"22"},{"groupId":"FG001","numSubjects":"55"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"10"},{"groupId":"FG001","numSubjects":"3"}],"type":"Withdrawal by Subject"},{"reasons":[{"groupId":"FG000","numSubjects":"24"},{"groupId":"FG001","numSubjects":"12"}],"type":"Progression/Relapse"},{"reasons":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"7"}],"type":"Death"},{"reasons":[{"groupId":"FG000","numSubjects":"24"},{"groupId":"FG001","numSubjects":"28"}],"type":"Not Protocol-Specified"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"229"},{"groupId":"FG001","numSubjects":"242"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"146"},{"groupId":"FG001","numSubjects":"137"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"83"},{"groupId":"FG001","numSubjects":"105"}],"type":"NOT COMPLETED"}],"title":"Induction Therapy"},{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"27"},{"groupId":"FG001","numSubjects":"31"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"6"},{"groupId":"FG001","numSubjects":"4"}],"type":"Withdrawal by Subject"},{"reasons":[{"groupId":"FG000","numSubjects":"67"},{"groupId":"FG001","numSubjects":"42"}],"type":"Progression/Relapse"},{"reasons":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"3"}],"type":"Death"},{"reasons":[{"groupId":"FG000","numSubjects":"14"},{"groupId":"FG001","numSubjects":"15"}],"type":"Not Protocol-Specified"},{"reasons":[{"groupId":"FG000","numSubjects":"26"},{"groupId":"FG001","numSubjects":"40"}],"type":"On Treatment"}],"milestones":[{"achievements":[{"comment":"3 patients who completed induction did not continue on to maintenance due to refusal (1), other (2).","groupId":"FG000","numSubjects":"143"},{"comment":"2 patients who completed induction did not continue on to maintenance due to other (2).","groupId":"FG001","numSubjects":"135"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"0"}],"comment":"Patients were treated until progression or removal/refusal. \"Completed\" does not apply.","type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"143"},{"groupId":"FG001","numSubjects":"135"}],"type":"NOT COMPLETED"}],"title":"Maintenance"}]}