{"classes":[{"categories":[{"measurements":[{"comment":"The median and 95 % CI was not estimable because there were too few events (low incidence of observed SREs) to calculate the median and 95 % CI.","groupId":"OG000","lowerLimit":"NA","upperLimit":"NA","value":"NA"},{"comment":"The median and 95 % CI was not estimable because there were too few events (low incidence of observed SREs) to calculate the median and 95 % CI.","groupId":"OG001","lowerLimit":"NA","upperLimit":"NA","value":"NA"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"42"}],"units":"Participants"}],"description":"The time to first SRE is defined as the date of enrollment to the date of the first occurrence of any SRE on the study. SRE includes pathological fracture, initiation of radiotherapy or surgery on bone, spinal cord compression, or HCM. Participants who drop-out was treated as censored observations. Time to first SRE on the study was assessed by the Kaplan-Meier method.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants received 4 mg or a reduced dose, i.e., 3.5 mg, or 3.3 mg or 3.0 mg of Zoledronic acid as an IV infusion over a minimum of 15 minutes every 12 weeks for up to 96 weeks based on the participants most recent urine NTx measurement ( \\<50 nmol/mmol creatinine).","id":"OG000","title":"Zoledronic Acid Every 12 Weeks"},{"description":"Participants received 4 mg or a reduced dose, i.e., 3.5 mg, or 3.3 mg or 3.0 mg of Zoledronic acid as an IV infusion over a minimum of 15 minutes every 4 weeks or every 12 weeks for up to 96 weeks based on the participants most recent urine NTx measurement (≥ 50 nmol/mmol creatinine or \\<50 nmol/mmol creatinine, respectively).","id":"OG001","title":"Zoledronic Acid Every 4 Weeks or 12 Weeks"}],"paramType":"MEDIAN","populationDescription":"ITT analysis set included all participants who were enrolled in this study.","reportingStatus":"POSTED","timeFrame":"Up to 2 years","title":"Time to First SRE on Study","type":"SECONDARY","unitOfMeasure":"years"}