{"eventGroups":[{"description":"Bortezomib 1.3mg/m\\^2 by IV days 1, 4, 8 \\& 11 Cyclophosphamide 300mg/m\\^2 PO days 1, 8, 15 \\& 22 Dexamethasone 40mg PO days 1-4, 9-12, 17-20","id":"EG000","otherNumAffected":33,"otherNumAtRisk":33,"seriousNumAffected":4,"seriousNumAtRisk":33,"title":"CyBorD (Bortezomib 1.3mg/m^2)"},{"description":"Bortezomib 1.5mg/m\\^2 by IV days 1, 8, 15 \\& 22 Cyclophosphamide 300mg/m\\^2 PO days 1, 8, 15 \\& 22 Dexamethasone 40mg PO cycle 1-2 days 1-4, 9-12, 17-20, cycle 3 and beyond days 1, 8, 15 \\& 22","id":"EG001","otherNumAffected":27,"otherNumAtRisk":30,"seriousNumAffected":3,"seriousNumAtRisk":30,"title":"CyBorD (Bortezomib 1.5mg/m^2)"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":33,"numEvents":6},{"groupId":"EG001","numAffected":2,"numAtRisk":30,"numEvents":2}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":2,"numAtRisk":30,"numEvents":4}],"term":"Hemolysis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Ischemia/Infarction"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Sinus tachycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":33,"numEvents":3},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Constipation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":3,"numAtRisk":30,"numEvents":5}],"term":"Diarrhea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Dyspepsia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Ileus"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":3,"numAtRisk":30,"numEvents":3}],"term":"Nausea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Vomiting"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":3,"numAtRisk":30,"numEvents":4}],"term":"Edema limbs"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":33,"numEvents":52},{"groupId":"EG001","numAffected":24,"numAtRisk":30,"numEvents":75}],"term":"Fatigue"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Bronchus infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Conjunctiva infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Infection without neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Upper airway infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Fracture"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Alanine aminotransferase increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Alkaline phosphatase increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Creatinine increased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Metabolic/Lab"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":14,"numAtRisk":33,"numEvents":30},{"groupId":"EG001","numAffected":7,"numAtRisk":30,"numEvents":16}],"term":"Neutrophil count decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":27,"numAtRisk":33,"numEvents":68},{"groupId":"EG001","numAffected":11,"numAtRisk":30,"numEvents":28}],"term":"Platelet count decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":33,"numEvents":7},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Hyperglycemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Hyperkalemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Hypocalcemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":33,"numEvents":2},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Hypokalemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Hyponatremia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Hypophosphatemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Back pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Bone pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":33,"numEvents":2},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Muscle Weakness"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":2},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Musculoskeletal"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Dizziness"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Ischemia cerebrovascular"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":21,"numAtRisk":33,"numEvents":52},{"groupId":"EG001","numAffected":17,"numAtRisk":30,"numEvents":64}],"term":"Peripheral sensory neuropathy"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Taste"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Tremor"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Anxiety"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":2},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Euphoria"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":33,"numEvents":4},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Insomnia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Aspiration"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":2,"numAtRisk":30,"numEvents":2}],"term":"Cough"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Dyspnea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Hiccups"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Pneumonitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Pulmonary"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Acne"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Erythema multiforme"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Hypertension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Hypotension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":33,"numEvents":2},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Thrombosis"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Febrile neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Colonic obstruction"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Blood Infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Lung (pneumonia) infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Neutrophil count decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Hypercalcemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Hyponatremia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Dyspnea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Pneumonitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":33,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":30,"numEvents":1}],"term":"Pulmonary"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA 9","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":33,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":30,"numEvents":0}],"term":"Thrombosis"}]}