{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.16","upperLimit":"9.15","value":"2.40"},{"groupId":"OG001","lowerLimit":"1.23","upperLimit":"8.95","value":"2.23"},{"groupId":"OG002","lowerLimit":"0.84","upperLimit":"3.40","value":"2.25"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"38"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"42"}],"units":"Participants"}],"description":"Cyclophosphamide plasma concentration-time data are collected on day 9 in one cycle of induction chemotherapy. Individual estimates of cyclophosphamide clearance are obtained using post hoc analysis.","dispersionType":"Full Range","groups":[{"description":"Patients with gross total resection (GTR)/no evidence of metastatic disease (M0) medulloblastoma, nodular desmoplastic histology, or high grade glioma","id":"OG000","title":"Low-Risk Group"},{"description":"Patients with no evidence of metastatic disease (M0) medulloblastoma or nodular desmoplastic histology with less than a gross total resection (GTR), other histologic diagnoses with no metastatic disease","id":"OG001","title":"Intermediate-Risk Group"},{"description":"Patients with central nervous system (CNS) metastatic disease","id":"OG002","title":"High-Risk Group"}],"paramType":"MEDIAN","populationDescription":"Eligible patients who received cyclophosphamide during a cycle of induction therapy and had samples collected for PK analysis..","reportingStatus":"POSTED","timeFrame":"Pre-infusion, end of infusion, 3, 6, and 24 hours from end of cyclophosphamide infusion","title":"Cyclophosphamide Clearance in Induction Chemotherapy","type":"SECONDARY","unitOfMeasure":"L/h/m^2"}