{"eventGroups":[{"description":"Patients receive melphalan, prednisone and thalidomide induction plus thalidomide maintenance (MPT-T).\n\nINDUCTION THERAPY: Patients receive melphalan PO and prednisone PO daily on days 1-4, and thalidomide PO daily on days 1-28. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.\n\nMAINTENANCE THERAPY: Patients receive thalidomide PO daily and continue in the absence of disease progression.","id":"EG000","otherNumAffected":29,"otherNumAtRisk":148,"seriousNumAffected":110,"seriousNumAtRisk":148,"title":"MPT-T"},{"description":"Patients receive lower-dose melphalan, prednisone and lenalidomide (Revlimid®) induction plus lenalidomide maintenance (mPR-R).\n\nINDUCTION THERAPY: Patients receive melphalan PO and prednisone PO daily on days 1-4, and lenalidomide PO on days 1-21. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.\n\nMAINTENANCE THERAPY: Patients receive lenalidomide PO daily on days 1-21. Courses repeat every 28 days in the absence of disease progression.","id":"EG001","otherNumAffected":34,"otherNumAtRisk":151,"seriousNumAffected":88,"seriousNumAtRisk":150,"title":"mPR-R"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":11,"numAtRisk":148},{"groupId":"EG001","numAffected":22,"numAtRisk":151}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":12,"numAtRisk":148},{"groupId":"EG001","numAffected":17,"numAtRisk":151}],"term":"White blood cell decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":148},{"groupId":"EG001","numAffected":9,"numAtRisk":151}],"term":"Lymphocyte count 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3.0","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":148},{"groupId":"EG001","numAffected":9,"numAtRisk":151}],"term":"Constipation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":148},{"groupId":"EG001","numAffected":2,"numAtRisk":151}],"term":"Peripheral sensory neuropathy"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Immune system disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":148},{"groupId":"EG001","numAffected":1,"numAtRisk":150}],"term":"Anaphylaxis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":16,"numAtRisk":148},{"groupId":"EG001","numAffected":11,"numAtRisk":150}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":148},{"groupId":"EG001","numAffected":1,"numAtRisk":150}],"term":"Hemolysis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":29,"numAtRisk":148},{"groupId":"EG001","numAffected":17,"numAtRisk":150}],"term":"White blood cell decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":21,"numAtRisk":148},{"groupId":"EG001","numAffected":10,"numAtRisk":150}],"term":"Lymphocyte count decreased"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Neoplasms benign, malignant and unspecified (incl cysts and polyps)","sourceVocabulary":"CTCAE 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disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":148},{"groupId":"EG001","numAffected":2,"numAtRisk":150}],"term":"Atrial fibrillation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":148},{"groupId":"EG001","numAffected":0,"numAtRisk":150}],"term":"Sinus bradycardia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":148},{"groupId":"EG001","numAffected":3,"numAtRisk":150}],"term":"Myocardial infarction"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":148},{"groupId":"EG001","numAffected":1,"numAtRisk":150}],"term":"Hypertension"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Vascular 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infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":148},{"groupId":"EG001","numAffected":1,"numAtRisk":150}],"term":"Tooth infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":148},{"groupId":"EG001","numAffected":3,"numAtRisk":150}],"term":"Joint infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE 3.0","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":148},{"groupId":"EG001","numAffected":3,"numAtRisk":150}],"term":"Lung infection"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"CTCAE 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