{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"2.1","upperLimit":"6.0","value":"4.9"},{"groupId":"OG001","lowerLimit":"1.2","upperLimit":"3.3","value":"2.2"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"description":"FES SUV prior to endocrine treatment (dichotomized and as a continuous predictor) will also be tested as predictor of time to progression. Analysis will be conducted using (respectively) logistic regression and Cox proportional hazards regression. This will include univariate analysis of FES and other predictive measures (ER/PgR expression, serum sex steroid levels), followed by an exploratory multivariate analysis combining FES SUV with other measures showing predictive capability univariate analysis.","dispersionType":"Full Range","groups":[{"description":"Patients undergo \\[\\^18F\\] FES PET scan. Patients also undergo standard clinical fludeoxyglucose F 18 (FDG)-PET or FDG-PET/CT scan up to 14 days prior to \\[\\^18F\\] FES PET scan.\n\nPatients begin clinically indicated endocrine therapy.\n\nPatients are followed-up to determine response on the therapy for 6 months using clinical exams, tumor marker assays, conventional imaging and standard clinical FDG PET/CT.\n\nThis group represents patients who had positive FES uptake at all disease sites on the baseline diagnostic FES PET scan.","id":"OG000","title":"Diagnostic (FES): Average FES SUVmean >1.5, no Negative Sites"},{"description":"Patients undergo \\[\\^18F\\] FES PET scan. Patients also undergo standard clinical fludeoxyglucose F 18 (FDG)-PET or FDG-PET/CT scan up to 14 days prior to \\[\\^18F\\] FES PET scan.\n\nPatients begin clinically indicated endocrine therapy.\n\nPatients are followed-up to determine response on the therapy for 6 months using clinical exams, tumor marker assays, conventional imaging and standard clinical FDG PET/CT.\n\nThis group represents patients who had some or all disease sites negative for FES uptake on the baseline diagnostic FES PET scan.","id":"OG001","title":"Diagnostic FES: Patients With FES Negative Sites of Disease"}],"paramType":"MEDIAN","reportingStatus":"POSTED","timeFrame":"Up to 6 months","title":"Time to Progression","type":"SECONDARY","unitOfMeasure":"months"}