{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"500"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"29"}],"units":"Participants"}],"groups":[{"description":"Patients receive vorinostat PO QD on days 1-5, ifosfamide IV continuously over 24 hours and carboplatin IV over 1 hour on day 4, and etoposide IV over 1 hour on days 3-5. Patients who are CD20+ also receive rituximab IV once on day 3, 4, or 5. Treatment repeats every 21 days for 2 courses in the absence of disease progression or unacceptable toxicity.\n\nvorinostat: Given PO\n\nrituximab: Given IV\n\nifosfamide: Given IV\n\ncarboplatin: Given IV\n\netoposide: Given IV\n\npharmacological study: Correlative studies\n\nlaboratory biomarker analysis: Correlative studies\n\ngene expression analysis: Correlative studies","id":"OG000","title":"Treatment (Enzyme Inhibitor, Monoclonal Antibody, Chemotherapy"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"28 days post last dose of study drug","title":"Maximum Tolerated Dose of Vorinostat","type":"PRIMARY","unitOfMeasure":"mg twice daily X 5 days"}