{"eventGroups":[{"description":"Patients receive vorinostat PO QD on days 1-5, ifosfamide IV continuously over 24 hours and carboplatin IV over 1 hour on day 4, and etoposide IV over 1 hour on days 3-5. Patients who are CD20+ also receive rituximab IV once on day 3, 4, or 5. Treatment repeats every 21 days for 2 courses in the absence of disease progression or unacceptable toxicity.\n\nvorinostat: Given PO\n\nrituximab: Given IV\n\nifosfamide: Given IV\n\ncarboplatin: Given IV\n\netoposide: Given IV\n\npharmacological study: Correlative studies\n\nlaboratory biomarker analysis: Correlative studies\n\ngene expression analysis: Correlative studies","id":"EG000","otherNumAffected":25,"otherNumAtRisk":29,"seriousNumAffected":10,"seriousNumAtRisk":29,"title":"Treatment (Enzyme Inhibitor, Monoclonal Antibody, Chemotherapy"}],"frequencyThreshold":"5","otherEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":29}],"term":"Febrile neutropenia"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":29}],"term":"Infection"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":29}],"term":"Nausea"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":29}],"term":"Dehydration"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":29}],"term":"Anorexia"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":29}],"term":"Vomiting"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":12,"numAtRisk":29}],"term":"Hypophasphataemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":10,"numAtRisk":29}],"term":"Hypokalaemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":29}],"term":"Hyponatraemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":29}],"term":"Hypercalcemia"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":29}],"term":"AST/ALT"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":29}],"term":"DVT"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":29}],"term":"Elevated PTT"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":29}],"term":"Pain"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":29}],"term":"Fatigue"},{"organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":29}],"term":"Hypoxia"}],"seriousEvents":[{"organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":29}],"term":"Dyspnea"},{"organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":29}],"term":"Encephalopathy"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":29}],"term":"Febrile neutropenia"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":29}],"term":"Nausea/Vomiting"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":29}],"term":"Diarrhea"},{"organSystem":"Vascular disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":29}],"term":"Hypotension"},{"organSystem":"Immune system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":29}],"term":"Allergic reaction"},{"organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":29}],"term":"Syncope"}]}