{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"57.7","upperLimit":"83.2","value":"71.7"},{"groupId":"OG001","lowerLimit":"21.2","upperLimit":"45.1","value":"32.3"},{"groupId":"OG002","lowerLimit":"17.5","upperLimit":"48.7","value":"31.6"},{"groupId":"OG003","lowerLimit":"5.4","upperLimit":"41.9","value":"19.0"},{"groupId":"OG004","lowerLimit":"51.7","upperLimit":"70.1","value":"61.2"},{"groupId":"OG005","lowerLimit":"0.2","upperLimit":"38.5","value":"8.3"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"65"},{"groupId":"OG002","value":"38"},{"groupId":"OG003","value":"18"},{"groupId":"OG004","value":"116"},{"groupId":"OG005","value":"66"}],"units":"Participants"}],"description":"ORR was defined as participants with a best overall response of complete response (CR) or partial response (PR) divided by the total number of evaluable participants per RECIST version 1.0 (RECIST1.1 for ALK-negative NSCLC cohort 1 and ALK-negative NSCLC cohort 2). CR: Disappearance of all target and non-target lesions, normalization of tumor marker levels, and no appearance of new lesions indicated complete response. PR: At least a 30% decrease in the sum of the longest diameters of target lesions (taking as reference the baseline sum), without progression of non-target lesions and no appearance of new lesions indicated partial response.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants received Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet orally twice daily (BID) with or without food for up to 105 cycles (each cycle 28 days).","id":"OG000","title":"RP2D Cohort: ROS1-Positive NSCLC: Crizotinib 250 mg"},{"description":"Participants received Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet orally twice daily (BID) with or without food for up to 55 cycles (each cycle 28 days).","id":"OG001","title":"RP2D Cohort: MET Exon 14 Alterations NSCLC: Crizotinib 250 mg"},{"description":"Participants received Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet orally twice daily (BID) with or without food for up to 101 cycles (each cycle 28 days).","id":"OG002","title":"RP2D Cohort: MET Amplification NSCLC: Crizotinib 250 mg"},{"description":"Participants received Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet orally BID with or without food for up to 70 cycles (each cycle 21 days).","id":"OG003","title":"RP2D Cohort: ALK-Negative Cohort 2, NSCLC: Crizotinib 250 mg"},{"description":"Participants received Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet twice daily (BID) with or without food for up to 133 cycles (each cycle 28 days).","id":"OG004","title":"RP2D Cohort: ALK-Positive Cohort, NSCLC: Crizotinib 250 mg"},{"description":"Participants received Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet orally twice daily (BID) with or without food for up to 54 cycles (each cycle 28 days).","id":"OG005","title":"RP2D Cohort: Enriched Other: Crizotinib 250 mg"}],"paramType":"NUMBER","populationDescription":"Response-evaluable population was defined as all participants in the SA set who had an adequate baseline disease assessment and had met 1 of the following 2 criteria: a) Had at least one post-baseline disease assessment b) withdrew from the trial or experienced progression/death at any time on study. Here, \"Overall number of participants Analyzed\" signifies number of participants evaluable for this outcome measure. Data was planned to be analyzed for reported arms only.","reportingStatus":"POSTED","timeFrame":"Baseline up to 172 months","title":"Recommended Phase 2 Dose (RP2D) Cohort: Percentage of Participants With Objective Response (OR)","type":"PRIMARY","unitOfMeasure":"percentage of participants"}