{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"36","value":"136.0"},{"groupId":"OG001","spread":"30","value":"214.0"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"description":"Ctrough refers to plasma concentration of Crizotinib observed just before treatment administration.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants received with or without food Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet QD from Cycle 1Day1 to Cycle 2 Day1 thereafter 250 mg BID from Cycle 2 Day 2 up to 58 cycles (each cycle 28 days).","id":"OG000","title":"RP2D Cohort: Itraconazole Interaction: Crizotinib 250 mg Alone"},{"description":"Participants received Crizotinib 250 mg (2 capsules/tablet of 100 mg each + 1 capsule/tablet of 50 mg) capsule/tablet QD from Cycle 1Day1 to Cycle 2 Day1 thereafter 250 mg BID from Cycle 2 Day 2 up to 58 cycles (each cycle 28 days). Participants also received Itraconazole 200 mg QD from Cycle 1 Day 1 to Cycle 1 Day 16. (each cycle 28 days).","id":"OG001","title":"RP2D Cohort: Itraconazole Interaction: Crizotinib 250 mg With Itraconazole"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK parameter evaluable population included participants who had at least 1 of the PK parameters of Crizotinib (AUCtau or Cmax) and had received 10 consecutive doses of both Crizotinib 250 mg QD and itraconazole 200 mg QD immediately prior to end of Crizotinib 250 mg + Itraconazole treatment as well as 10 consecutive doses of Crizotinib 250 mg QD prior to end of Crizotinib 250 mg + Itraconazole treatment. Overall number of participants analyzed =participants evaluable for this outcome measure.","reportingStatus":"POSTED","timeFrame":"pre-dose on Cycle 1 Day 15 (crizotinib with itraconazole) and Cycle 2 Day 1 (itraconazole alone)","title":"Itraconazole Cohort: Trough Plasma Concentration (Ctrough) of Crizotinib When Taken Alone and When Taken With Itraconazole","type":"PRIMARY","unitOfMeasure":"nanogram per milliliter"}