{"analyses":[{"ciNumSides":"TWO_SIDED","groupIds":["OG001"],"nonInferiorityComment":"The study was designed as a standard dose-escalation study, dose-finding pilot study. The primary outcome measures were safety (hypercalcemia, hypophosphatemia and symptoms/hemodynamic measurements). A modified Fibronacci dose-escalation scheme was employed.","nonInferiorityType":"NON_INFERIORITY_OR_EQUIVALENCE","pValue":".002","pValueComment":"the reported p-value corresponds to the increase comapred to baseline over time (days 2-8) in the PTHrP 4 pmol group","statisticalComment":"The level of statistical significance was set at .05 (two-tailed)","statisticalMethod":"Mixed Models Analysis","testedNonInferiority":true}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.91","value":"1.93"},{"groupId":"OG001","spread":"0.73","value":"2.57"},{"groupId":"OG002","spread":"0.59","value":"2.38"}]}],"title":"Baseline"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.59","value":"1.31"},{"groupId":"OG001","spread":"0.46","value":"2.26"},{"groupId":"OG002","spread":"2.42","value":"4.11"}]}],"title":"Day 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.51","value":"1.07"},{"groupId":"OG001","spread":"0.61","value":"2.85"},{"groupId":"OG002","spread":"0.45","value":"3.27"}]}],"title":"Day 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.25","value":"1.57"},{"groupId":"OG001","spread":"0.76","value":"2.79"},{"groupId":"OG002","spread":"0.40","value":"2.14"}]}],"title":"Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.70","value":"3.05"},{"groupId":"OG001","spread":"0.46","value":"2.05"},{"groupId":"OG002","spread":"0.46","value":"3.12"}]}],"title":"Day 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.67","value":"3.37"},{"groupId":"OG001","spread":"0.25","value":"2.75"},{"groupId":"OG002","spread":"2.23","value":"5.42"}]}],"title":"Day 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.28","value":"2.72"},{"groupId":"OG001","spread":"0.38","value":"3.94"},{"groupId":"OG002","spread":"0.73","value":"4.13"}]}],"title":"Day 7"}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"description":"% calculated from daily second morning void","dispersionType":"Standard Error","groups":[{"description":"PTHrP(1-36) 2 picomoles/kg/hr for one week.","id":"OG000","title":"Group 1"},{"description":"PTHrP(1-36) 4 picomoles/kg/hr for one week","id":"OG001","title":"Group 2"},{"description":"PTHrP(1-36) 5 picomoles/kg/hr for one week","id":"OG002","title":"Group 3"},{"description":"PTHrP(1-36) 6 picomoles/kg/hr for one week","id":"OG003","title":"Group 4"}],"paramType":"MEAN","reportingStatus":"POSTED","timeFrame":"daily","title":"Fractional Excretion of Calcium","type":"SECONDARY","unitOfMeasure":"% of filtered load"}