{"analyses":[{"ciNumSides":"TWO_SIDED","groupIds":["OG000","OG001","OG002"],"nonInferiorityComment":"The study was designed as a standard dose-escalation study, dose-finding pilot study. The primary outcome measures were safety (hypercalcemia, hypophosphatemia and symptoms/hemodynamic measurements). A modified Fibronacci dose-escalation scheme was employed.","nonInferiorityType":"NON_INFERIORITY_OR_EQUIVALENCE","pValue":"<0.05","pValueComment":"the reported p-values correspond to the decrease compared to baseline in all arms/groups at Days 2-8","statisticalComment":"The level of statistical significance was set at .05 (two-tailed)","statisticalMethod":"Mixed Models Analysis","testedNonInferiority":true}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"2.86","value":"42.97"},{"groupId":"OG001","spread":"5.56","value":"30.70"},{"groupId":"OG002","spread":"15.93","value":"48.27"}]}],"title":"baseline"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.48","value":"23.47"},{"groupId":"OG001","spread":"1.50","value":"7.82"},{"groupId":"OG002","spread":"0.50","value":"3.60"}]}],"title":"Day 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.65","value":"21.43"},{"groupId":"OG001","spread":"1.75","value":"5.23"},{"groupId":"OG002","spread":"0.00","value":"3.00"}]}],"title":"Day 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.24","value":"26.77"},{"groupId":"OG001","spread":"3.21","value":"7.88"},{"groupId":"OG002","spread":"0.00","value":"3.00"}]}],"title":"Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.10","value":"22.37"},{"groupId":"OG001","spread":"1.80","value":"7.54"},{"groupId":"OG002","spread":"0.00","value":"3.00"}]}],"title":"Day 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.88","value":"21.13"},{"groupId":"OG001","spread":"2.24","value":"6.57"},{"groupId":"OG002","spread":"0.00","value":"3.00"}]}],"title":"Day 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.03","value":"19.40"},{"groupId":"OG001","spread":"1.20","value":"5.67"},{"groupId":"OG002","spread":"0.00","value":"3.00"}]}],"title":"Day 7"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.58","value":"12.60"},{"groupId":"OG001","spread":"0.00","value":"3.00"},{"groupId":"OG002","spread":"0.00","value":"3.00"}]}],"title":"Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.18","value":"56.37"},{"groupId":"OG001","spread":"2.63","value":"31.60"},{"groupId":"OG002","spread":"10.87","value":"44.20"}]}],"title":"follow-up"}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"description":"pg/ml","dispersionType":"Standard Error","groups":[{"description":"PTHrP(1-36) 2 picomoles/kg/hr for one week.","id":"OG000","title":"Group 1"},{"description":"PTHrP(1-36) 4 picomoles/kg/hr for one week.","id":"OG001","title":"Group 2"},{"description":"PTHrP(1-36) 5 picomoles/kg/hr for one week.","id":"OG002","title":"Group 3"},{"description":"PTHrP(1-36) 6 picomoles/kg/hr for one week.","id":"OG003","title":"Group 4"}],"paramType":"MEAN","reportingStatus":"POSTED","timeFrame":"Baseline and Daily","title":"Parathyroid Hormone (1-84)","type":"SECONDARY","unitOfMeasure":"pg/ml"}