{"analyses":[{"ciNumSides":"TWO_SIDED","groupIds":["OG001"],"nonInferiorityComment":"The study was designed as a standard dose-escalation study, dose-finding pilot study. The primary outcome measures were safety (hypercalcemia, hypophosphatemia and symptoms/hemodynamic measurements). A modified Fibronacci dose-escalation scheme was employed.","nonInferiorityType":"NON_INFERIORITY_OR_EQUIVALENCE","pValue":"<0.0001","pValueComment":"The reported p-value corresponds to the increase over time for the PTHrP 4 pmol group.","statisticalComment":"Value The level of statistical significance was set at .05 (two-tailed)","statisticalMethod":"Mixed Models Analysis","testedNonInferiority":true}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.07","value":"9.37"},{"groupId":"OG001","spread":"0.12","value":"9.58"},{"groupId":"OG002","spread":"0.25","value":"9.2"}]}],"title":"baseline"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.09","value":"9.67"},{"groupId":"OG001","spread":"0.16","value":"9.80"},{"groupId":"OG002","spread":"0.20","value":"9.67"}]}],"title":"11P DAY 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.17","value":"9.4"},{"groupId":"OG001","spread":"0.19","value":"10.05"},{"groupId":"OG002","spread":"0.20","value":"10.17"}]}],"title":"7A DAY 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.09","value":"9.57"},{"groupId":"OG001","spread":"0.14","value":"10.28"},{"groupId":"OG002","spread":"0.30","value":"10.47"}]}],"title":"3P DAY 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.09","value":"9.67"},{"groupId":"OG001","spread":"0.14","value":"10.32"},{"groupId":"OG002","spread":"0.26","value":"10.23"}]}],"title":"11P DAY 2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.10","value":"9.6"},{"groupId":"OG001","spread":"0.18","value":"10.40"},{"groupId":"OG002","spread":"0.57","value":"10.73"}]}],"title":"7A DAY 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.09","value":"9.73"},{"groupId":"OG001","spread":"0.14","value":"10.42"},{"groupId":"OG002","spread":"0.27","value":"10.67"}]}],"title":"3P DAY 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.17","value":"9.40"},{"groupId":"OG001","spread":"0.10","value":"9.73"},{"groupId":"OG002","spread":"0.38","value":"9.93"}]}],"title":"11P DAY 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.03","value":"9.47"},{"groupId":"OG001","spread":"0.24","value":"10.00"},{"groupId":"OG002","spread":"0.23","value":"10.3"}]}],"title":"7A DAY 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.17","value":"9.40"},{"groupId":"OG001","spread":"0.21","value":"9.92"},{"groupId":"OG002","spread":"0.34","value":"10.33"}]}],"title":"3P DAY 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.09","value":"9.37"},{"groupId":"OG001","spread":"0.11","value":"9.48"},{"groupId":"OG002","spread":"0.15","value":"10.00"}]}],"title":"11P DAY 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.12","value":"9.30"},{"groupId":"OG001","spread":"0.12","value":"9.62"},{"groupId":"OG002","spread":"0.15","value":"10.53"}]}],"title":"7A DAY 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.15","value":"9.50"},{"groupId":"OG001","spread":"0.20","value":"9.83"},{"groupId":"OG002","spread":"0.44","value":"10.27"}]}],"title":"3P DAY 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.09","value":"9.43"},{"groupId":"OG001","spread":"0.13","value":"9.45"},{"groupId":"OG002","spread":"0.20","value":"9.80"}]}],"title":"11P DAY 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.07","value":"9.57"},{"groupId":"OG001","spread":"0.20","value":"9.83"},{"groupId":"OG002","spread":"0.22","value":"10.53"}]}],"title":"7A DAY 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.15","value":"9.43"},{"groupId":"OG001","spread":"0.12","value":"10.08"},{"groupId":"OG002","spread":"0.27","value":"10.83"}]}],"title":"3P DAY 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.13","value":"9.43"},{"groupId":"OG001","spread":"0.21","value":"9.67"},{"groupId":"OG002","spread":"0.47","value":"10.43"}]}],"title":"11P DAY 6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.10","value":"9.40"},{"groupId":"OG001","spread":"0.28","value":"10.13"},{"groupId":"OG002","spread":"0.46","value":"10.90"}]}],"title":"7A DAY 7"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.15","value":"9.70"},{"groupId":"OG001","spread":"0.32","value":"10.22"},{"groupId":"OG002","spread":"0.46","value":"10.70"}]}],"title":"3P DAY 7"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.15","value":"9.60"},{"groupId":"OG001","spread":"0.28","value":"10.27"},{"groupId":"OG002","spread":"0.50","value":"10.73"}]}],"title":"11P DAY 7"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.13","value":"9.83"},{"groupId":"OG001","spread":"0.40","value":"10.67"},{"groupId":"OG002","spread":"0.35","value":"11.17"}]}],"title":"7A DAY 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.07","value":"9.33"},{"groupId":"OG001","spread":"0.12","value":"9.80"},{"groupId":"OG002","spread":"0.24","value":"9.17"}]}],"title":"FOLLOW-UP"}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"description":"mg/dl","dispersionType":"Standard Error","groups":[{"description":"PTHrP(1-36) 2 picomoles/kg/hr","id":"OG000","title":"Group 1"},{"description":"PTHrP(1-36) 4 picomoles/kg/hr","id":"OG001","title":"Group 2"},{"description":"PTHrP (1-36) 5 pmol/kg/hr","id":"OG002","title":"Group 3"},{"description":"PTHrP (1-36) 6 picomoles/kg/hr","id":"OG003","title":"Group 4"}],"paramType":"MEAN","reportingStatus":"POSTED","timeFrame":"12 hours after the infusion was started then q 8 hours for 7 days, Follow-up 1 week after infusion complete","title":"Total Serum Calcium","type":"PRIMARY","unitOfMeasure":"mg/dl"}