{"description":"All participants included in the Short and Long Term Analysis populations. Other (non-serious)Adverse Events were not collected for this study.","eventGroups":[{"description":"Participants received standard care for multiple myeloma which included: For the Short term study: Total Therapy II Chemotherapy Regimen (See Protocol) and Stem Cell Harvest. For the Long term study: Total Therapy II Chemotherapy Regimen (See Protocol) and melphalan with autologous peripheral-blood stem cell transplantation (PBSCT). For both the short and long term studies, red blood cell (RBC) and platelet transfusions were administered as needed, in addition to Epoetic Alfa (EPO) when hemoglobin levels dropped during high dose chemotherapy. The usual EPO dose is 150 units/kg of body weight, three times per week, or 40,000 units weekly, with suggested target hemoglobin range of 10-12 g/dl. Study participants were asked to remain as active as possible but not prescribed an individualized exercise program. Participants were stratified by thalidomide administration and by age (\\<=60 versus \\>60).Participants who received thalidomide also received low-molecular weight heparin","id":"EG000","otherNumAffected":0,"otherNumAtRisk":0,"seriousNumAffected":17,"seriousNumAtRisk":62,"title":"Usual Care"},{"description":"Participants received standard care for multiple myeloma which included: For the Short term study: Total Therapy II Chemotherapy Regimen (See Protocol) and Stem Cell Harvest. For the Long term study: Total Therapy II Chemotherapy Regimen (See Protocol) and melphalan with autologous peripheral-blood stem cell transplantation (PBSCT). For both the short and long term studies, red blood cell (RBC) and platelet transfusions as needed, in addition to Epoetic Alfa (EPO) when hemoglobin levels dropped during high dose chemotherapy. The usual EPO dose is 150 units/kg of body weight, three times per week, or 40,000 units weekly, with suggested target hemoglobin range of 10-12 g/dl. Study participants were computer randomized to an individualized exercise program that incorporated aerobic and strength resistance training. Participants were stratified by thalidomide administration and by age (\\<=60 versus \\>60). Participants who received thalidomide also received low-molecular weight heparin.","id":"EG001","otherNumAffected":0,"otherNumAtRisk":0,"seriousNumAffected":25,"seriousNumAtRisk":58,"title":"Exercise"}],"frequencyThreshold":"0","seriousEvents":[{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Anemia"},{"organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Atrial fibrillation"},{"organSystem":"Musculoskeletal and connective tissue disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Compression fracture"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Death"},{"organSystem":"Vascular disorders","stats":[{"groupId":"EG000","numAffected":11,"numAtRisk":62},{"groupId":"EG001","numAffected":10,"numAtRisk":58}],"term":"Deep Vein Thrombosis (DVT)"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Dehydration"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":0,"numAtRisk":58}],"term":"Fluid overload"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":62},{"groupId":"EG001","numAffected":3,"numAtRisk":58}],"term":"Hyperglycemia"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":5,"numAtRisk":58}],"term":"Hyponatremia"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Infection / sepsis"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Mucositis / diarrhea"},{"organSystem":"Cardiac disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Myocardial infarction"},{"organSystem":"Immune system disorders","stats":[{"groupId":"EG000","numAffected":11,"numAtRisk":62},{"groupId":"EG001","numAffected":8,"numAtRisk":58}],"term":"Neutropenic fever"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Pain"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58}],"term":"Pneumonia"},{"organSystem":"Vascular disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":62},{"groupId":"EG001","numAffected":2,"numAtRisk":58}],"term":"Pulmonary embolus"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":0,"numAtRisk":58}],"term":"Rectal abcesses"},{"organSystem":"Renal and urinary disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":0,"numAtRisk":58}],"term":"Renal failure"},{"organSystem":"Renal and urinary disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":0,"numAtRisk":58}],"term":"Renal stone"},{"organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":0,"numAtRisk":58}],"term":"Respiratory distress"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":62},{"groupId":"EG001","numAffected":1,"numAtRisk":58,"numEvents":59}],"term":"Ruptured diverticulum"},{"organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":62},{"groupId":"EG001","numAffected":0,"numAtRisk":58}],"term":"Syncope"}],"timeFrame":"up to 30 weeks"}