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Stage 2 and 3 patients will receive Induction chemotherapy and External Beam Radiation Therapy, but will not receive Consolidation therapy (High-Dose Chemotherapy with Stem Cell Rescue).","id":"OG000","title":"Stage 2/3 Patients"},{"description":"Patients with overt distant metastatic disease (such as bone, bone marrow, and/or liver) but no detectable CNS involvement. Patients will receive Induction chemotherapy, Stem Cell Harvesting, Consolidation with Stem Cell Rescue, and depending on response to Induction chemotherapy, possibly External Beam Radiation Therapy.","id":"OG001","title":"Stage 4a Patients"},{"description":"Patients with overt CNS involvement (brain parenchyma, leptomeninges and CSF cytology). Patients with trilateral retinoblastoma will be included. Patients will receive Induction chemotherapy, Stem Cell Harvesting, Consolidation with Stem Cell Rescue, and depending on response to Induction chemotherapy, possibly External Beam Radiation Therapy.","id":"OG002","title":"Stage 4b Patients"}],"paramType":"NUMBER","populationDescription":"Three ineligible patients were excluded from this analysis. Two patients who did not receive therapy were also excluded from this analysis.","reportingStatus":"POSTED","timeFrame":"Up to 30 days after completion of study treatment","title":"Percentage of Participants With Adverse Events as Assessed by the Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0","type":"SECONDARY","unitOfMeasure":"percentage of participants"}