{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"60","upperLimit":"97","value":"88"},{"groupId":"OG001","lowerLimit":"55","upperLimit":"94","value":"83"},{"groupId":"OG002","lowerLimit":"10","upperLimit":"49","value":"28"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"19"},{"groupId":"OG001","value":"18"},{"groupId":"OG002","value":"20"}],"units":"Participants"}],"description":"The probability of surviving patients who did not experience events at 1 year following enrollment. An event is defined as relapse, second malignancy, or death from any cause.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients with orbital disease (including microscopic trans-scleral invasion seen on enucleation pathology), optic nerve margin (+), and/or regional nodal disease, but no other sites of metastases. Stage 2 and 3 patients will receive Induction chemotherapy and External Beam Radiation Therapy, but will not receive Consolidation therapy (High-Dose Chemotherapy with Stem Cell Rescue).","id":"OG000","title":"Stage 2/3 Patients"},{"description":"Patients with overt distant metastatic disease (such as bone, bone marrow, and/or liver) but no detectable CNS involvement. Patients will receive Induction chemotherapy, Stem Cell Harvesting, Consolidation with Stem Cell Rescue, and depending on response to Induction chemotherapy, possibly External Beam Radiation Therapy.","id":"OG001","title":"Stage 4a Patients"},{"description":"Patients with overt CNS involvement (brain parenchyma, leptomeninges and CSF cytology). Patients with trilateral retinoblastoma will be included. Patients will receive Induction chemotherapy, Stem Cell Harvesting, Consolidation with Stem Cell Rescue, and depending on response to Induction chemotherapy, possibly External Beam Radiation Therapy.","id":"OG002","title":"Stage 4b Patients"}],"paramType":"NUMBER","populationDescription":"Ineligible patients were excluded from analysis","reportingStatus":"POSTED","timeFrame":"At 1 year","title":"Event-free Survival (EFS)","type":"PRIMARY","unitOfMeasure":"Probability"}