{"groups":[{"description":"1200cGy = 150cGy x 8 doses: Patients receive busulfan IV once daily over 2 hours on days -15 and -13 and then every 6 hours on days -12 to -9. Patients also receive etoposide IV on day -3. Patients undergo image-guided intensity-modulated radiation therapy using helical tomotherapy on days -8 to -5.\n\nTRANSPLANTATION: Patients undergo allogeneic peripheral blood stem cell transplantation or bone marrow transplantation on day 0.\n\nGRAFT-VS-HOST DISEASE (GVHD) PROPHYLAXIS: Patients receive GVHD prophylaxis that excludes methotrexate.\n\nbusulfan: Given IV\n\netoposide: Given IV\n\nintensity-modulated radiation therapy: Initially 150 cGy X 8 doses with gradual dose escalation to 200 cGy X 10 doses\n\nallogeneic hematopoietic stem cell transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\nallogeneic bone marrow transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\nperipheral blood stem cell transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\ntomotherapy: Initially 150 cGy X 8 doses with gradual dose escalation to 200 cGy X 10 doses","id":"FG000","title":"Arm I: 1200cGy"},{"description":"1350cGy = 150cGy x 9 doses: Patients receive busulfan IV once daily over 2 hours on days -15 and -13 and then every 6 hours on days -12 to -9. Patients also receive etoposide IV on day -3. Patients undergo image-guided intensity-modulated radiation therapy using helical tomotherapy on days -8 to -5.\n\nbusulfan: Given IV\n\netoposide: Given IV\n\nintensity-modulated radiation therapy: Initially 150 cGy X 8 doses with gradual dose escalation to 200 cGy X 10 doses\n\nallogeneic hematopoietic stem cell transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\nallogeneic bone marrow transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\nperipheral blood stem cell transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\ntomotherapy: Initially 150 cGy X 8 doses with gradual dose escalation to 200 cGy X 10 doses","id":"FG001","title":"Arm II: 1350cGy"}],"periods":[{"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"23"},{"groupId":"FG001","numSubjects":"2"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"23"},{"groupId":"FG001","numSubjects":"2"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"0"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}]}