{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"1200"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"}],"units":"Participants"}],"description":"The highest dose tested in which fewer than 33% of patients experienced DLT attributable to the study treatment when at least six patients were treated at the dose and are evaluable for toxicity. The MDT is one dose level below the DLT level. At least six patients will be treated at the MTD.","groups":[{"description":"1200cGy = 150cGy x 8 doses: Patients receive busulfan IV once daily over 2 hours on days -15 and -13 and then every 6 hours on days -12 to -9. Patients also receive etoposide IV on day -3. Patients undergo image-guided intensity-modulated radiation therapy using helical tomotherapy on days -8 to -5.\n\nTRANSPLANTATION: Patients undergo allogeneic peripheral blood stem cell transplantation or bone marrow transplantation on day 0.\n\nGRAFT-VS-HOST DISEASE (GVHD) PROPHYLAXIS: Patients receive GVHD prophylaxis that excludes methotrexate.\n\nbusulfan: Given IV\n\netoposide: Given IV\n\nintensity-modulated radiation therapy: Initially 150 cGy X 8 doses with gradual dose escalation to 200 cGy X 10 doses\n\nallogeneic hematopoietic stem cell transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\nallogeneic bone marrow transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\nperipheral blood stem cell transplantation: Stem cell transplantation occurs on Day 0 after High Dose Therapy\n\ntomotherapy: Initially 150 cGy X 8 doses with gradual dose escalation to 200 cGy X 10 doses","id":"OG000","title":"Arm I: 1200cGy"}],"paramType":"NUMBER","populationDescription":"6 patients treated at dose level one (1200cGy) are evaluable for dose limiting evaluable in Phase I.","reportingStatus":"POSTED","timeFrame":"from initial treatment date to Day 30 post-transplant","title":"Maximum Tolerated Dose (MTD) of Intensity-modulated Radiation Therapy (Phase I)","type":"PRIMARY","unitOfMeasure":"cGy"}