{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"184"},{"groupId":"OG001","value":"374"}]}],"title":"Calcium (hypocalcemia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"140"},{"groupId":"OG001","value":"246"}]}],"title":"Calcium (hypocalcemia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"42"},{"groupId":"OG001","value":"122"}]}],"title":"Calcium (hypocalcemia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"}]}],"title":"Calcium (hypocalcemia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"}]}],"title":"Calcium (hypocalcemia), Increase to G4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"}]}],"title":"Calcium (hypercalcemia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"1"}]}],"title":"Calcium (hypercalcemia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"0"}]}],"title":"Calcium (hypercalcemia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"title":"Calcium (hypercalcemia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"title":"Calcium (hypercalcemia), Increase to G4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"90"}]}],"title":"Glu. (hypoglycemia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"45"}]}],"title":"Glu. (hypoglycemia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"31"}]}],"title":"Glu. (hypoglycemia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"9"}]}],"title":"Glu. (hypoglycemia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"5"}]}],"title":"Glu. (hypoglycemia), Increase to G4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"128"},{"groupId":"OG001","value":"277"}]}],"title":"Glu. (hyperglycemia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"68"}]}],"title":"Glu. (hyperglycemia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"77"},{"groupId":"OG001","value":"161"}]}],"title":"Glu. (hyperglycemia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"19"},{"groupId":"OG001","value":"44"}]}],"title":"Glu. (hyperglycemia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"4"}]}],"title":"Glu. (hyperglycemia), Increase to G4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"15"}]}],"title":"Pot. (hyperkalemia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"7"}]}],"title":"Pot. (hyperkalemia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"3"}]}],"title":"Pot. (hyperkalemia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"}]}],"title":"Pot. (hyperkalemia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"}]}],"title":"Pot. (hyperkalemia), Increase to G4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"74"}]}],"title":"Pot. (hypokalemia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"48"},{"groupId":"OG001","value":"66"}]}],"title":"Pot. (hypokalemia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"6"}]}],"title":"Pot. (hypokalemia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"}]}],"title":"Pot. (hypokalemia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"title":"Pot. (hypokalemia), Increase to G4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"21"}]}],"title":"Sod. (hypernatremia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"20"}]}],"title":"Sod. (hypernatremia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"}]}],"title":"Sod. (hypernatremia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"title":"Sod. (hypernatremia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"title":"Sod. (hypernatremia), Increase to G4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"72"},{"groupId":"OG001","value":"128"}]}],"title":"Sod. (hyponatremia), Any Grade Increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"69"},{"groupId":"OG001","value":"118"}]}],"title":"Sod. (hyponatremia), Increase to G1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"8"}]}],"title":"Sod. (hyponatremia), Increase to G2"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"}]}],"title":"Sod. (hyponatremia), Increase to G3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"}]}],"title":"Sod. (hyponatremia), Increase to G4"}],"denoms":[{"counts":[{"groupId":"OG000","value":"252"},{"groupId":"OG001","value":"506"}],"units":"Participants"}],"description":"Blood samples for the assessment of clinical chemistry parameters were taken at intervals throughout the study. Participants with the worst-case shift from BL during the DB Phase are reported, per severity grades by DAIDS, for levels of calcium (low=hypocalcemia; high=hypercalcemia), glu. (low=hypoglycemia; high=hyperglycemia), pot. (low=hypokalemia; high=hyperkalemia), and sod. (low=hyponatremia; high=hypernatremia). Per the DAIDS toxicity table, the grade ranges for each parameter are as follows: Grade (G) 1=mild; G2=moderate; G3=severe; G4=potentially life-threatening.","groups":[{"description":"Participants completing the OL Phase were administered matching placebo tablets QD in combination with antiviral therapy (peginterferon alfa-2b and ribavirin) for a duration of either 24 or 48 weeks (for participants with Genotype 2/3) or 48 weeks (for participants with Non-Genotype 2/3).","id":"OG000","title":"Placebo+Antiviral Therapy: DB Phase"},{"description":"Participants completing the OL Phase continued on the same dose of eltrombopag received in the OL Phase (dose that effectively raised platelets to \\>=100 Gi/L) in combination with antiviral therapy (peginterferon alfa-2b and ribavirin) for a duration of either 24 or 48 weeks (for participants with Genotype 2/3) or 48 weeks (for participants with Non-Genotype 2/3).","id":"OG001","title":"Eltrombopag+Antiviral Therapy: DB Phase"}],"paramType":"NUMBER","populationDescription":"Safety DB Population: all randomized participants who had received study drug in the DB Phase","reportingStatus":"POSTED","timeFrame":"From Baseline up to Week 48 or Week 72 (for participants with Genotype 2/3) or up to Week 72 (for participants with Non-Genotype 2/3)","title":"Number of Participants With the Indicated Shift From Baseline (BL) in Severity Grades for Clinical Chemistry Parameters (Calcium, Glucose [Glu.], Potassium [Pot.], and Sodium [Sod.]), Per Division of Acquired Immunodeficiency Syndrome (DAIDS)","type":"SECONDARY","unitOfMeasure":"participants"}