{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"11.2"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"80"}],"units":"Participants"}],"description":"Continual reassessment method (four times a day) used to determine an MTD, with a target toxicity probability of 20%, where \"toxicity\" is defined as grade 3 or 4 conventional toxicity \\[National Cancer Institute Common Toxicity Criteria (NCI-CTC)\\]. Participant evaluation in a cohort with each modality is 30 days.","groups":[{"description":"Busulfan starting 0.8 mg/kg by vein (IV) every 6 hours for 12 doses; Fludarabine 30 mg/m\\^2 IV daily for 4 days.","id":"OG000","title":"Busulfan + Fludarabine"}],"paramType":"NUMBER","populationDescription":"Analysis was per protocol.","reportingStatus":"POSTED","timeFrame":"1 month","title":"Maximum Tolerated Dose (MTD)","type":"PRIMARY","unitOfMeasure":"mg/kg"}