{"denoms":[{"counts":[{"groupId":"OG000","value":"0"}],"units":"Participants"}],"description":"Maximum tolerated dose found using a standard 3+3 dose escalation model.","groups":[{"description":"Subjects will be started on recombinant interferon-α at a dose of 3 million units SQ daily, escalating the dose by 1 million units every week as tolerated to a maximum dose of 3 million units/m2/day. Following a minimum of one month of interferon therapy with two weeks on a stable dose, subjects will begin recombinant interleukin-6 therapy at a dose of 2.5 ug/kg/day.\n\nrecombinant interferon-α\n\nrecombinant interleukin-6","id":"OG000","title":"Interleukin-6 and Interferon-α"}],"populationDescription":"This outcome cannot be evaluated as zero participants tolerated the study regimen. All participants were enrolled on the 2.5 mg arm and a maximum tolerated dose was not found.","reportingStatus":"POSTED","timeFrame":"Up to 5 months","title":"Optimal Dose of Interleukin-6","type":"PRIMARY"}