{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.17","value":"-0.4"},{"groupId":"OG001","spread":"1.60","value":"-1.9"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"201"},{"groupId":"OG001","value":"298"}],"units":"Participants"}],"description":"The disease activity score (DAS28) is an evaluation index of rheumatoid arthritis. The DAS28 applies a mathematical formula based on the following parameters: 1. TJC-28 joints, 2. SJC -28 joints, 3. ESR or CRP measurement, 4. Participant's judgement on his own overall health (global health \\[GH\\]) status expressed by a VAS (0 \\[no disease activity\\] to 100 \\[maximum disease activity\\]). The mathematical formula is 0.56 × √28TJC + 0.28 × √28SJC + 0.7 x loge ESR + 0.014 × GH. The DAS28 scale ranges from score of 0 to 10, where lower scores indicate best disease control and higher scores indicate worsening of disease. Change from Baseline = difference between the score at Week 24 and the score at Baseline.","dispersionType":"Standard Deviation","groups":[{"description":"Eligible participants were administered placebo by intravenous infusion on Days 1 and 15 along with MTX 10-25 mg p.o. or parenterally once a week up to 24 weeks and were followed up to Week 104.","id":"OG000","title":"Placebo Plus Methotrexate"},{"description":"Eligible Participants were administered rituximab 1000 mg as intravenous infusion on Days 1 and 15 along with MTX 10-25 mg p.o. or parenterally once a week up to Week 24 and were followed up to Week 104.","id":"OG001","title":"Rituximab Plus Methotrexate"}],"paramType":"MEAN","populationDescription":"The ITT population included all randomized participants who received any part of an infusion of study drug. Participants whom treatment allocation was unblinded and who received treatment prior to randomization were excluded.","reportingStatus":"POSTED","timeFrame":"From Baseline (Day 1) to Week 24","title":"Mean Change From Baseline in Disease Activity Score of 28 Joints at Week 24","type":"SECONDARY","unitOfMeasure":"units on a scale"}