{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"10"},{"groupId":"OG002","value":"11"}]}],"title":"Acute GVHD grade >=II"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"3"}]}],"title":"Acute GVHD grades III and IV"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"2"}]}],"title":"Chronic GVHD; intermediate/severe"}],"denoms":[{"counts":[{"groupId":"OG000","value":"18"},{"groupId":"OG001","value":"18"},{"groupId":"OG002","value":"18"}],"units":"Participants"}],"description":"GVHD can be mild, moderate or severe depending on the differences in tissue type between patient and donor. GVHD can be acute or chronic. Its symptoms can include:\n\n* Rashes, which include burning and redness, that erupt on the palms or soles and may spread to the trunk and eventually to the entire body\n* Blistering, causing the exposed skin surface to flake off in severe cases\n* Nausea, vomiting, abdominal cramps, diarrhea and loss of appetite, which can indicate that the gastrointestinal (digestive) tract is affected\n* Jaundice, or a yellowing of the skin, which can indicate liver damage\n* Excessive dryness of the mouth and throat, leading to ulcers\n* Dryness of the lungs, vagina and other surfaces","groups":[{"description":"Participants with the lowest tertile of measured busulfan Area under the curve (AUC); with a mean value of 5078 (full range 3933-5615) microM/min","id":"OG000","title":"Low Busulfan AUC Tertile"},{"description":"Participants with the lowest tertile of measured busulfan Area under the curve (AUC); with a mean value of 6372 (full range 5639-6965) microM/min","id":"OG001","title":"Intermediate Busulfan AUC Tertile"},{"description":"Participants with the lowest tertile of measured busulfan Area under the curve (AUC); with a mean value of 7605 (full range 7054-8863) microM/min","id":"OG002","title":"High Busulfan AUC Tertile"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Because AUC levels varied between the groups and the goal was to identify an actual achieved AUC-based dose, additional outcome analyses were undertaken by dividing patients into thirds according to the actual AUCs delivered rather than the original planned AUCs.","reportingStatus":"POSTED","timeFrame":"100 days post transplant","title":"Incidence of Graft vs Host Disease in Patients Between One Month and Two Years Post Transplant","type":"SECONDARY","unitOfMeasure":"Participants"}