{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"11.7"},{"groupId":"OG001","value":"4.9"},{"groupId":"OG002","value":"10.2"},{"groupId":"OG003","value":"11.1"},{"groupId":"OG004","value":"15.9"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"24"},{"groupId":"OG003","value":"7"},{"groupId":"OG004","value":"2"}],"units":"Participants"}],"description":"Test doses of busulfan were administered and plasma levels were measured to determine a targeted AUC dosing estimate. The capacity is reported as the precision with which these test dose goals predicted the actual 90-hour mean AUC levels.Dose targeting precision was estimated by root mean squared error.","groups":[{"description":"Target AUC/24 hrs of 4800 uM-min +/-15%","id":"OG000","title":"Dose Level 1"},{"description":"Target AUC/24 hrs of 5760 uM-min +/- 15%","id":"OG001","title":"Dose Level 2"},{"description":"Target AUC/24 hrs of 6912 uM-min +/- 15%","id":"OG002","title":"Dose Level 3"},{"description":"Target AUC/24 hrs of 7603 uM-min+/- 15%","id":"OG003","title":"Dose Level 4"},{"description":"Target AUC/24 hrs of 8363 uM-min+/- 15%","id":"OG004","title":"Dose Level 5"}],"paramType":"NUMBER","reportingStatus":"POSTED","timeFrame":"Day -15 to Day -11","title":"Capacity of Test Dosing of Busulfan That Would Result in the Desired Area Under the Curve Concentration Exposure of Patients Receiving a Full-dose Busulfan Regimen","type":"SECONDARY","unitOfMeasure":"percentage of error"}