{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"2.86","value":"133.2"},{"groupId":"OG001","spread":"13.11","value":"121.3"},{"groupId":"OG002","spread":"19.29","value":"128.8"}]}],"title":"Baseline (n=6, 6, 21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.65","value":"138.8"},{"groupId":"OG001","spread":"8.56","value":"116.4"},{"groupId":"OG002","spread":"17.38","value":"129.5"}]}],"title":"Infusion (0 minutes) (n=6, 5, 19)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.03","value":"136.7"},{"groupId":"OG001","spread":"8.64","value":"117.3"},{"groupId":"OG002","spread":"16.54","value":"125.5"}]}],"title":"15 minutes post infusion (n=6,6,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.71","value":"139.2"},{"groupId":"OG001","spread":"10.82","value":"119.8"},{"groupId":"OG002","spread":"14.00","value":"124.0"}]}],"title":"30 minutes post infusion (n=6,6,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.19","value":"141.2"},{"groupId":"OG001","spread":"5.79","value":"111.5"},{"groupId":"OG002","spread":"14.38","value":"123.5"}]}],"title":"45 minutes post infusion (n=6,6,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.78","value":"142.3"},{"groupId":"OG001","spread":"5.69","value":"115.0"},{"groupId":"OG002","spread":"14.39","value":"124.8"}]}],"title":"60 minutes post infusion (n=6,6,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.69","value":"134.0"},{"groupId":"OG001","spread":"10.21","value":"119.3"},{"groupId":"OG002","spread":"18.01","value":"126.2"}]}],"title":"75 minutes post infusion (n=5,3,12)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.62","value":"134.0"},{"groupId":"OG001","spread":"8.76","value":"119.0"},{"groupId":"OG002","spread":"14.24","value":"126.1"}]}],"title":"90 minutes post infusion (n=4,4,14)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.74","value":"141.2"},{"groupId":"OG001","spread":"15.69","value":"120.6"},{"groupId":"OG002","spread":"16.72","value":"121.2"}]}],"title":"1 hour post infusion (n= 6,5,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.91","value":"131.3"},{"groupId":"OG001","spread":"11.04","value":"119.7"},{"groupId":"OG002","spread":"14.76","value":"123.4"}]}],"title":"2 hour post infusion (n= 6,6,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.79","value":"133.5"},{"groupId":"OG001","spread":"12.24","value":"122.2"},{"groupId":"OG002","spread":"15.29","value":"125.4"}]}],"title":"3 hour post infusion (n= 6,5,19)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.94","value":"133.0"},{"groupId":"OG001","spread":"19.61","value":"128.5"},{"groupId":"OG002","spread":"13.20","value":"125.9"}]}],"title":"4 hour post infusion (n= 6,6,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.63","value":"137.0"},{"groupId":"OG001","spread":"14.21","value":"130.0"},{"groupId":"OG002","spread":"15.77","value":"124.6"}]}],"title":"6 hour post infusion (n= 6,6,21)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.81","value":"144.8"},{"groupId":"OG001","spread":"19.36","value":"130.6"},{"groupId":"OG002","spread":"12.21","value":"130.6"}]}],"title":"8 hour post infusion (n= 5,5,21)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"21"}],"units":"Participants"}],"description":"Systolic blood pressures (SBPs) measured in millimeters of mercury (mmHg) were obtained while the participant was seated. Baseline, Infusion (0 minutes) and Post infusion SBPs are presented in the 1 mg, 3 mg and 10 mg cohorts at: 15, 30, 45, 60, 75, and 90 minutes post infusion and at 1, 2, 3, 4, 6, 8 hours post infusion. Baseline was defined as the last measurement before the first dose of study drug, which was calculated from pre-dose or from screening if pre-dose was not available. Mean SBPs on Day 1 for first dose (cycle 1) are presented below.","dispersionType":"Standard Deviation","groups":[{"description":"1 mg of nivolumab per kg of body weight was administered in a single IV infusion over 60 minutes on Day 1. Eligible participants could be re-treated and receive 2 more doses (1 dose every 4 weeks) at same dose as the single dose if: disease was stable, no drug intolerance was observed, no CR or PR was observed, or they had a positive immunogenicity sample within 4 weeks prior to re-treatment. Those who responded to therapy with a CR or PR were eligible for long-term follow-up until either PD or 2 years elapsed.","id":"OG000","title":"1 mg/kg Nivolumab"},{"description":"3 mg of nivolumab per kg of body weight was administered in a single IV infusion over 60 minutes on Day 1. Eligible participants could be re-treated and receive 2 more doses (1 dose every 4 weeks) at same dose as the single dose if: disease was stable, no drug intolerance was observed, no CR or PR was observed, or they had a positive immunogenicity sample within 4 weeks prior to re-treatment. Those who responded to therapy with a CR or PR were eligible for long-term follow-up until either PD or 2 years elapsed.","id":"OG001","title":"3 mg/kg Nivolumab"},{"description":"10 mg of nivolumab per kg of body weight was administered in a single IV infusion over 60 minutes on Day 1. Eligible participants could be re-treated and receive 2 more doses (1 dose every 4 weeks) at same dose as the single dose if: disease was stable, no drug intolerance was observed, no CR or PR was observed, or they had a positive immunogenicity sample within 4 weeks prior to re-treatment. Those who responded to therapy with a CR or PR were eligible for long-term follow-up until either PD or 2 years elapsed.","id":"OG002","title":"10 mg/kg Nivolumab"}],"paramType":"MEAN","populationDescription":"All participants who received at least 1 dose or any partial dose of nivolumab and had available blood pressure at baseline and post-infusion were analyzed.","reportingStatus":"POSTED","timeFrame":"Baseline, Day 1","title":"Mean Systolic Blood Pressure at Baseline and Post-Infusion Day 1 (Cycle 1) in in 1mg, 3mg, and 10 mg Cohorts - Safety Population","type":"SECONDARY","unitOfMeasure":"mmHg"}