{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.16","value":"80.3"}]}],"title":"Baseline (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.01","value":"82.4"}]}],"title":"Infusion (0 minutes) (n=5)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.28","value":"87.0"}]}],"title":"21 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.88","value":"81.0"}]}],"title":"36 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.20","value":"79.8"}]}],"title":"51 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.71","value":"80.3"}]}],"title":"66 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.69","value":"81.7"}]}],"title":"82 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.56","value":"80.3"}]}],"title":"97 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.14","value":"78.7"}]}],"title":"112 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.14","value":"81.0"}]}],"title":"127 minutes post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.36","value":"72.5"}]}],"title":"157 minutes post infusion (n=2)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.96","value":"80.5"}]}],"title":"1 hour post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.02","value":"82.2"}]}],"title":"2 hour post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.35","value":"74.5"}]}],"title":"3 hour post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.08","value":"73.8"}]}],"title":"4 hour post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.44","value":"78.2"}]}],"title":"6 hour post infusion (n=6)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.67","value":"76.2"}]}],"title":"8 hour post infusion (n=6)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"}],"units":"Participants"}],"description":"Diastolic blood pressures (DBPs) measured in millimeters of mercury (mmHg) were obtained while the participant was seated. Post infusion DBPs are presented in the 0.3 mg cohort at: 21, 36, 51, 66, 82, 97, 112, 127, 157 minutes post infusion, and at 1, 2, 3, 4, 6, 8 hours post infusion. Baseline was defined as the last measurement before the first dose of study drug, which was calculated from pre-dose or from screening if pre-dose was not available. Mean DBP on Day 1 for first dose (cycle 1) are presented below.","dispersionType":"Standard Deviation","groups":[{"description":"0.3 mg of nivolumab per kg of body weight (mg/kg) was administered in a single IV infusion on Day 1 with 10% of the dose infused over 6 minutes and after a 1 hour observation period, the balance was administered over 60 minutes. Eligible participants could be re-treated and receive 2 more doses (1 dose every 4 weeks) at same dose as the single dose if: disease was stable, no drug intolerance was observed, no CR or PR was observed, or they had a positive immunogenicity sample within 4 weeks prior to re-treatment. Those who responded to therapy with a CR or PR were eligible for long-term follow-up until either PD or 2 years elapsed.","id":"OG000","title":"0.3 mg/kg Nivolumab"}],"paramType":"MEAN","populationDescription":"All participants who received at least 1 dose or any partial dose of nivolumab and had available blood pressure at baseline and post-infusion were analyzed.","reportingStatus":"POSTED","timeFrame":"Baseline, Day 1","title":"Mean Diastolic Blood Pressure at Baseline and Post-Infusion Day 1 (Cycle 1) in 0.3 mg Cohort - Safety Population","type":"SECONDARY","unitOfMeasure":"mmHg"}