{"denoms":[{"counts":[{"groupId":"OG000","value":"0"}],"units":"Participants"}],"description":"The change in the prevalence/expression of these markers between pre-and-post treatment samples will be analyzed by McNemar's test. Ninety-five percent confidence intervals will be calculated to assess the precision of the obtained estimates for all laboratory correlates.","groups":[{"description":"Patients receive aflibercept IV over 1 hour on day 1. Treatment repeats every 2 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity.\n\naflibercept: Given IV","id":"OG000","title":"Treatment (Antiangiogenesis Therapy)"}],"populationDescription":"data not collected","reportingStatus":"POSTED","timeFrame":"At baseline, before every course for 3 months, and then every 3 months during treatment for the first year","title":"Circulating Endothelial Progenitors","type":"SECONDARY"}