{"analyses":[{"ciNumSides":"TWO_SIDED","groupIds":["OG000","OG001","OG002","OG003"],"nonInferiorityComment":"A sample size of 80 patients per arm will provide\\> 80% power to detect differences between average hemoglobin levels in the\\> reference arm and another treatment of 50% of the standard deviation. Note that\\> typically one would expect the estimates for the standard deviation at a single time\\> point to differ from the standard deviation for the difference from baseline.","nonInferiorityType":"NON_INFERIORITY_OR_EQUIVALENCE","pValue":">0.13","statisticalMethod":"Fisher Exact","testedNonInferiority":true}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"28","upperLimit":"37","value":"32"},{"groupId":"OG001","lowerLimit":"35","upperLimit":"68","value":"50"},{"groupId":"OG002","lowerLimit":"35","upperLimit":"77","value":"49"},{"groupId":"OG003","lowerLimit":"35","upperLimit":"64","value":"49"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"61"},{"groupId":"OG001","value":"60"},{"groupId":"OG002","value":"58"},{"groupId":"OG003","value":"57"}],"units":"Participants"}],"description":"To compare the effects of the 3 different epoetin alfa dosing schedules and a darbepoetin alfa schedule","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients receive Epoetin alfa 40,000 units subcutaneously every week for 15 weeks (15 doses)","id":"OG000","title":"Epoetin Alfa - 40k Weekly"},{"description":"Patients receive Epoetin alfa 80,000 units subcutaneously every 3 weeks for 15 weeks (5 doses)","id":"OG001","title":"Epoetin Alfa - 80k Every 3 Weeks"},{"description":"Patients receive Epoetin alfa 120,000 units subcutaneously every 3 weeks for 15 weeks (5 doses)","id":"OG002","title":"Epoetin Alfa - 120k Every 3 Weeks"},{"description":"Patients receive Darbepoetin alfa 500 micrograms (mcg) subcutaneously every 3 weeks for 15 weeks (5 doses)","id":"OG003","title":"Darbepoetin Alfa - 500 mcg Every 3 Weeks"}],"paramType":"MEDIAN","populationDescription":"All patients that were evaluable per protocol and had hemoglobin levels data.","reportingStatus":"POSTED","timeFrame":"16 weeks","title":"Time Required to Achieve Hemoglobin Levels >= 11.5 g/dL","type":"SECONDARY","unitOfMeasure":"days"}