{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"29.8","value":"68.1"},{"groupId":"OG001","spread":"39.3","value":"76.7"}]}],"title":"C-max"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.4","value":"7.9"},{"groupId":"OG001","spread":"12.3","value":"19.8"}]}],"title":"C-min"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.0","value":"19.0"},{"groupId":"OG001","spread":"10.9","value":"30.4"}]}],"title":"C-avg"}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"12"}],"units":"Participants"}],"description":"Blood samples will be collected by direct venipuncture during regularly scheduled visits according to the collection plan provided in the study protocol. C-avg= Area under curve (AUC) in a dosing interval from time-zero to time of the last quantifiable concentration (AUC0-tlast)/ time of the last quantifiable concentration in a dosing interval (tlast)","dispersionType":"Standard Deviation","groups":[{"description":"Pharmacokinetic Blood Sampling: Full pharmacokinetic profile assessments on Cycle 1, Day 1 (at pre-dose and at 1h, 2h, 5h, and 24h post-dose) were performed. Troughs were collected for all patients on Day 1 of each treatment Cycle from month 2 until discontinuation from the study drug.","id":"OG000","title":"Day 1"},{"description":"Pharmacokinetic Blood Sampling: Full pharmacokinetic profile assessments on Cycle 1, Day 15 (at pre-dose and at 1h, 2h, 5h, and 24h post-dose) were performed.","id":"OG001","title":"Day 15"}],"paramType":"MEAN","populationDescription":"The pharmacokinetics population consists of all patients who have a pharmacokinetic assessment with a sufficient number of evaluable blood samples. The analsyis was limited to RAD001 + BSC arm.","reportingStatus":"POSTED","timeFrame":"At pre-dose and post-dose: 1 hour, 2 hour, 5 hour, 24 hour of Cycle 1 Day1, Cycle 1 Day 15 and at pre-dose from Cycle 2(day1) and all subsequent treatment cycles up until data cut-off 28 Feb 2008.","title":"Pharmacokinetics of RAD001:Peak Concentration in a Dosing Interval (C-max); Pre-dose Concentration at 24-h Time Point in Dosing Interval (C-min) and Average Concentration in a Dosing Interval =(C-avg)","type":"SECONDARY","unitOfMeasure":"ng/mL"}