{"description":"No patients were enrolled on arms A2 and A3 because dose escalation was never triggered.","eventGroups":[{"deathsNumAffected":10,"deathsNumAtRisk":36,"description":"Arm A - patients with MPD or MDS-RA/RARS Dose Level 1 - 300 cGy TBI\n\nNONMYELOABLATIVE CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV on days -4 to -2 and undergo TBI on day 0.\n\nPBSC TRANSPLANTATION: Patients undergo filgrastim-mobilized PBSC infusion after TBI on day 0.\n\nIMMUNOSUPPRESSION:\n\nMatched Related Donor: Patients receive cyclosporine PO BID on days -3 to 56, followed by a taper until day 180. Patients also receive MMF PO BID beginning 4-6 hours after transplantation on day 0 and continue until day 27.\n\nUnrelated Donor: Patients receive cyclosporine PO BID on days -3 to 100, followed by a taper until day 180. Patients also receive MMF PO three times daily beginning 4-6 hours after transplantation on day 0 and continue until day 40, followed by a taper until day 96.","id":"EG000","otherNumAffected":16,"otherNumAtRisk":36,"seriousNumAffected":3,"seriousNumAtRisk":36,"title":"Arm A - Dose Level 1"},{"deathsNumAffected":0,"deathsNumAtRisk":0,"description":"Arm A - patients with MPD or MDS-RA/RARS Dose Level 2 - 400 cGy TBI\n\nNONMYELOABLATIVE CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV on days -4 to -2 and undergo TBI on day 0.\n\nPBSC TRANSPLANTATION: Patients undergo filgrastim-mobilized PBSC infusion after TBI on day 0.\n\nIMMUNOSUPPRESSION:\n\nMatched Related Donor: Patients receive cyclosporine PO BID on days -3 to 56, followed by a taper until day 180. Patients also receive MMF PO BID beginning 4-6 hours after transplantation on day 0 and continue until day 27.\n\nUnrelated Donor: Patients receive cyclosporine PO BID on days -3 to 100, followed by a taper until day 180. Patients also receive MMF PO three times daily beginning 4-6 hours after transplantation on day 0 and continue until day 40, followed by a taper until day 96.","id":"EG001","otherNumAffected":0,"otherNumAtRisk":0,"seriousNumAffected":0,"seriousNumAtRisk":0,"title":"Arm A - Dose Level 2"},{"deathsNumAffected":0,"deathsNumAtRisk":0,"description":"Arm A - patients with MPD or MDS-RA/RARS Dose Level 3 - 450 cGy TBI\n\nNONMYELOABLATIVE CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV on days -4 to -2 and undergo TBI on day 0.\n\nPBSC TRANSPLANTATION: Patients undergo filgrastim-mobilized PBSC infusion after TBI on day 0.\n\nIMMUNOSUPPRESSION:\n\nMatched Related Donor: Patients receive cyclosporine PO BID on days -3 to 56, followed by a taper until day 180. Patients also receive MMF PO BID beginning 4-6 hours after transplantation on day 0 and continue until day 27.\n\nUnrelated Donor: Patients receive cyclosporine PO BID on days -3 to 100, followed by a taper until day 180. Patients also receive MMF PO three times daily beginning 4-6 hours after transplantation on day 0 and continue until day 40, followed by a taper until day 96.","id":"EG002","otherNumAffected":0,"otherNumAtRisk":0,"seriousNumAffected":0,"seriousNumAtRisk":0,"title":"Arm A - Dose Level 3"},{"deathsNumAffected":10,"deathsNumAtRisk":12,"description":"Arm B - patients with MDS-RAEB or CMML Dose Level 1 - 300 cGy TBI\n\nNONMYELOABLATIVE CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV on days -4 to -2 and undergo TBI on day 0.\n\nPBSC TRANSPLANTATION: Patients undergo filgrastim-mobilized PBSC infusion after TBI on day 0.\n\nIMMUNOSUPPRESSION:\n\nMatched Related Donor: Patients receive cyclosporine PO BID on days -3 to 56, followed by a taper until day 180. Patients also receive MMF PO BID beginning 4-6 hours after transplantation on day 0 and continue until day 27.\n\nUnrelated Donor: Patients receive cyclosporine PO BID on days -3 to 100, followed by a taper until day 180. Patients also receive MMF PO three times daily beginning 4-6 hours after transplantation on day 0 and continue until day 40, followed by a taper until day 96.","id":"EG003","otherNumAffected":9,"otherNumAtRisk":12,"seriousNumAffected":7,"seriousNumAtRisk":12,"title":"Arm B - Dose Level 1"},{"deathsNumAffected":3,"deathsNumAtRisk":5,"description":"Arm B - patients with MDS-RAEB or CMML Dose Level 2 - 400 cGy TBI\n\nNONMYELOABLATIVE CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV on days -4 to -2 and undergo TBI on day 0.\n\nPBSC TRANSPLANTATION: Patients undergo filgrastim-mobilized PBSC infusion after TBI on day 0.\n\nIMMUNOSUPPRESSION:\n\nMatched Related Donor: Patients receive cyclosporine PO BID on days -3 to 56, followed by a taper until day 180. Patients also receive MMF PO BID beginning 4-6 hours after transplantation on day 0 and continue until day 27.\n\nUnrelated Donor: Patients receive cyclosporine PO BID on days -3 to 100, followed by a taper until day 180. Patients also receive MMF PO three times daily beginning 4-6 hours after transplantation on day 0 and continue until day 40, followed by a taper until day 96.","id":"EG004","otherNumAffected":2,"otherNumAtRisk":5,"seriousNumAffected":2,"seriousNumAtRisk":5,"title":"Arm B - Dose Level 2"},{"deathsNumAffected":9,"deathsNumAtRisk":24,"description":"Arm B - patients with MDS-RAEB or CMML Dose Level 3 - 450 cGy TBI\n\nNONMYELOABLATIVE CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV on days -4 to -2 and undergo TBI on day 0.\n\nPBSC TRANSPLANTATION: Patients undergo filgrastim-mobilized PBSC infusion after TBI on day 0.\n\nIMMUNOSUPPRESSION:\n\nMatched Related Donor: Patients receive cyclosporine PO BID on days -3 to 56, followed by a taper until day 180. Patients also receive MMF PO BID beginning 4-6 hours after transplantation on day 0 and continue until day 27.\n\nUnrelated Donor: Patients receive cyclosporine PO BID on days -3 to 100, followed by a taper until day 180. Patients also receive MMF PO three times daily beginning 4-6 hours after transplantation on day 0 and continue until day 40, followed by a taper until day 96.","id":"EG005","otherNumAffected":13,"otherNumAtRisk":24,"seriousNumAffected":4,"seriousNumAtRisk":24,"title":"Arm B - Dose Level 3"}],"frequencyThreshold":"0","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":36,"numEvents":0},{"groupId":"EG001","numAffected":0,"numAtRisk":0,"numEvents":0},{"groupId":"EG002","numAffected":0,"numAtRisk":0,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":12,"numEvents":1},{"groupId":"EG004","numAffected":0,"numAtRisk":5,"numEvents":0},{"groupId":"EG005","numAffected":0,"numAtRisk":24,"numEvents":0}],"term":"Abdominal pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Renal and urinary 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