{"eventGroups":[{"description":"Patients receive rituximab IV and doxorubicin hydrochloride IV over 15 minutes on day 1, cyclophosphamide IV over 30-60 minutes on days 1 and 2, pegfilgrastim SC on day 3, vincristine IV on days 1 and 8, high-dose methotrexate IV over 2-4 hours on day 15, and leucovorin calcium IV beginning 24 hours after the start of methotrexate and continuing every 6 hours until level is adequate. Patients receive CNS prophylaxis of methotrexate IT, cytarabine IT, and hydrocortisone IT on day 1. Patients with high-risk disease receive an additional dose of cytarabine IT on day 3. Patients also receive G-CSF SC once daily on days 3-9. Once the methotrexate levels drops below 50 nmol/L, patients resume G-CSF SC once daily beginning on approximately day 18 and continuing until blood counts recover.","id":"EG000","otherNumAffected":0,"otherNumAtRisk":2,"seriousNumAffected":0,"seriousNumAtRisk":2,"title":"Regimen A (R-CODOX-M Chemotherapy)"},{"description":"Patients receive rituximab IV on day 1, ifosfamide IV continuously and etoposide IV continuously over 24 hours on days 1-5, and high-dose cytarabine IV over 1-3 hours twice daily on days 1-2. Patients receive CNS prophylaxis comprising methotrexate IT and hydrocortisone IT on day 5. Patients also receive pegfilgrastim SC once 24-48 hours after completion of chemotherapy OR G-CSF SC beginning on day 6 and continuing until blood counts recover. Patients with CNS involvement (leptomeningeal and/or intraparenchymal) at diagnosis do not receive CNS prophylaxis as above. Instead, these patients receive a combination of sequential liposomal cytarabine and methotrexate IT or via an Ommaya reservoir on day 1 and then every 14 days as tolerated until completion of systemic chemotherapy.","id":"EG001","otherNumAffected":22,"otherNumAtRisk":32,"seriousNumAffected":23,"seriousNumAtRisk":32,"title":"Regimen B (Rituximab and IVAC Chemotherapy)"}],"frequencyThreshold":"5","otherEvents":[{"organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":15,"numAtRisk":32,"numEvents":34}],"term":"Anemia"},{"organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":3,"numAtRisk":32,"numEvents":4}],"term":"Febrile neutropenia"},{"organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA 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(10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":6,"numAtRisk":32,"numEvents":14}],"term":"Aspartate aminotransferase increased"},{"organSystem":"Investigations","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":3,"numAtRisk":32,"numEvents":6}],"term":"Blood bilirubin increased"},{"organSystem":"Investigations","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":2,"numAtRisk":32,"numEvents":5}],"term":"Lymphocyte count decreased"},{"organSystem":"Investigations","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":14,"numAtRisk":32,"numEvents":26}],"term":"Neutrophil count decreased"},{"organSystem":"Investigations","sourceVocabulary":"MedDRA 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(10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":4,"numAtRisk":32,"numEvents":9}],"term":"Hyponatremia"},{"organSystem":"Metabolism and nutrition disorders","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":5,"numAtRisk":32,"numEvents":10}],"term":"Hypophosphatemia"},{"organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":4,"numAtRisk":32,"numEvents":5}],"term":"Headache"},{"organSystem":"Psychiatric disorders","sourceVocabulary":"MedDRA (10.0)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":2,"numEvents":0},{"groupId":"EG001","numAffected":2,"numAtRisk":32,"numEvents":2}],"term":"Confusion"},{"organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA 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