{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"26"}]}],"title":"ALP, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"ALP, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"ALP, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"39"}]}],"title":"ALT, any grade increase, n=78"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"ALT, increase to Grade 3, n=78"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"ALT, increase to Grade 4, n=78"},{"categories":[{"measurements":[{"groupId":"OG000","value":"43"}]}],"title":"AST, any grade increase, n=78"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"}]}],"title":"AST, increase to Grade 3, n=78"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"AST, increase to Grade 4, n=78"},{"categories":[{"measurements":[{"groupId":"OG000","value":"26"}]}],"title":"Creatinine, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Creatinine, increase Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Creatinine, increase Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"}]}],"title":"Hypercalcemia, any grade increase, n=71"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hypercalcemia, increase to Grade 3, n=71"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hypercalcemia, increase to Grade 4, n=71"},{"categories":[{"measurements":[{"groupId":"OG000","value":"46"}]}],"title":"Hyperglycemia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hyperglycemia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hyperglycemia, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"28"}]}],"title":"Hyperkalemia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"Hyperkalemia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hyperkalemia, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"15"}]}],"title":"Hypermagnesemia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hypermagnesemia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hypermagnesemia, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"9"}]}],"title":"Hypernatremia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypernatremia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypernatremia, increae to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"30"}]}],"title":"Hypocalcemia, any grade increase, n=71"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hypocalcemia, increase to Grade 3, n=71"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypocalcemia, increase to Grade 4, n=71"},{"categories":[{"measurements":[{"groupId":"OG000","value":"12"}]}],"title":"Hypoglycemia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypoglycemia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Hypoglycemia, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"15"}]}],"title":"Hypokalemia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypokalemia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypokalemia, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"17"}]}],"title":"Hypomagnesemia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypomagnesemia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hypomagnesemia, increase Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"29"}]}],"title":"Hyponatremia, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"}]}],"title":"Hyponatremia, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Hyponatremia, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"32"}]}],"title":"Phosphate, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"Phosphate, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Phosphate, increase to Grade 4, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"40"}]}],"title":"TB, any grade increase, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"TB, increase to Grade 3, n=77"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"TB, increase to Grade 4, n=77"}],"denoms":[{"counts":[{"groupId":"OG000","value":"80"}],"units":"Participants"}],"description":"Clinical chemistry parameters were summarized according to NCI CTCAE, version 4.0: Grade 1, mild; Grade 2, moderate; Grade 3, severe; Grade 4, life-threatening or disabling; Grade 5, death. Data are presented for only those parameters for which an increase from Baseline occurred. Clinical chemistry parameters included: alkaline phosphatase (ALP), alanine amino transferase (ALT), aspartate amino transferase (AST), total bilirubin (TB), calcium (hypercalcemia and hypocalcemia), creatinine, glucose (hyperglycemia and hypoglycemia), potassium (hyperkalemia and hypokalemia), magnesium (hypermagnesemia and hypomagnesemia), sodium (hypernatremia and hyponatremia), and phosphate.","groups":[{"description":"Participants received pazopanib 800 milligrams (mg) once daily.","id":"OG000","title":"Pazopanib 800 mg"}],"paramType":"NUMBER","populationDescription":"ATS Population. Only those participants available at the specified time points were analyzed (represented by n=X in the category titles). Different participants may have been analyzed for different parameters, so the overall number of participants analyzed reflects everyone in the ATS Population.","reportingStatus":"POSTED","timeFrame":"From Baseline to investigational product discontinuation (up to 6.230 years)","title":"Number of Participants With the Indicated Worst-case Toxicity Grade Increase From Baseline for the Indicated Clinical Chemistry Parameters at Any Time Post-Baseline","type":"PRIMARY","unitOfMeasure":"participants"}