{"groups":[{"description":"Preparative regimen of total body irradiation (TBI) 200 cGy BID days -8,-7, \\& -6, Thiotepa IV (dose 5 mg/kg/day on days -5 \\& -4) \\& cyclophosphamide IV (dose 60 mg/kg/day on days -3 \\& -2). Tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally daily on day -2 with a taper starting on day 42 - day 98 (patients undergoing matched sibling donor transplantation) OR tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally daily beginning on day -2 followed by a taper on day 100 through day 180 (patients undergoing other related, unrelated, or cord blood donor transplantation) in the absence of GVHD. Patients also receive methotrexate IV (5 mg/m2/dose) on days 1,3, \\& 6 (patients with matched sibling and umbilical cord blood donors) OR days 1,3 6, \\& 11 (patients with other related/unrelated bone marrow and peripheral blood stem cell donors) and oral sirolimus (dose 2.5mg/m2/day - 4 mg max starting dose) daily starting on day 0 followed by a taper starting on day 180 through day 207.","id":"FG000","title":"Tacro-MTX/Sirolimus GVHD Prophylaxis Regimen"},{"description":"Preparative regimen of total body irradiation (TBI) 200 cGy BID days -8,-7, \\& -6, Thiotepa IV (dose 5 mg/kg/day on days -5 \\& -4) \\& cyclophosphamide IV (dose 60 mg/kg/day on days -3 \\& -2). Tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally (when able) daily on day -2 with a taper starting on day 42 - day 98 (patients undergoing matched sibling donor transplantation) OR tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally daily beginning on day -2 followed by a taper on day 100 through day 180 (patients undergoing other related, unrelated, or cord blood donor transplantation) in the absence of GVHD. Patients also receive methotrexate IV (5 mg/m2/dose) on days 1,3, \\& 6 (patients with matched sibling and umbilical cord blood donors) OR days 1,3 6, \\& 11 (patients with other related/unrelated bone marrow and peripheral blood stem cell donors).","id":"FG001","title":"Tacro-MTX GVHD Prophylaxis"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"0"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"6"},{"groupId":"FG001","numSubjects":"1"}],"type":"Physician Decision"},{"reasons":[{"groupId":"FG000","numSubjects":"1"},{"groupId":"FG001","numSubjects":"0"}],"type":"Withdrawal by Subject"},{"reasons":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"0"}],"type":"ineligible"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"2"}],"type":"Other"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"1"}],"type":"consent withdrawal"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"76"},{"groupId":"FG001","numSubjects":"70"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"64"},{"groupId":"FG001","numSubjects":"66"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"12"},{"groupId":"FG001","numSubjects":"4"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}]}