{"denoms":[{"counts":[{"groupId":"BG000","value":"76"},{"groupId":"BG001","value":"70"},{"groupId":"BG002","value":"146"}],"units":"Participants"}],"groups":[{"description":"Preparative regimen of total body irradiation (TBI) 200 cGy BID days -8,-7, \\& -6, Thiotepa IV (dose 5 mg/kg/day on days -5 \\& -4) \\& cyclophosphamide IV (dose 60 mg/kg/day on days -3 \\& -2). Tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally daily on day -2 with a taper starting on day 42 - day 98 (patients undergoing matched sibling donor transplantation) OR tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally daily beginning on day -2 followed by a taper on day 100 through day 180 (patients undergoing other related, unrelated, or cord blood donor transplantation) in the absence of GVHD. Patients also receive methotrexate IV (5 mg/m2/dose) on days 1,3, \\& 6 (patients with matched sibling and umbilical cord blood donors) OR days 1,3 6, \\& 11 (patients with other related/unrelated bone marrow and peripheral blood stem cell donors) and oral sirolimus (dose 2.5mg/m2/day - 4 mg max starting dose) daily starting on day 0 followed by a taper starting on day 180 through day 207.","id":"BG000","title":"Tacro-MTX/Sirolimus GVHD Prophylaxis Regimen"},{"description":"Preparative regimen of total body irradiation (TBI) 200 cGy BID days -8,-7, \\& -6, Thiotepa IV (dose 5 mg/kg/day on days -5 \\& -4) \\& cyclophosphamide IV (dose 60 mg/kg/day on days -3 \\& -2). Tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally (when able) daily on day -2 with a taper starting on day 42 - day 98 (patients undergoing matched sibling donor transplantation) OR tacrolimus IV (dose 0.02 mg/kg/day) continuously or orally daily beginning on day -2 followed by a taper on day 100 through day 180 (patients undergoing other related, unrelated, or cord blood donor transplantation) in the absence of GVHD. Patients also receive methotrexate IV (5 mg/m2/dose) on days 1,3, \\& 6 (patients with matched sibling and umbilical cord blood donors) OR days 1,3 6, \\& 11 (patients with other related/unrelated bone marrow and peripheral blood stem cell donors).","id":"BG001","title":"Tacro-MTX GVHD Prophylaxis"},{"description":"Total of all reporting groups","id":"BG002","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","lowerLimit":"1","upperLimit":"20","value":"9"},{"groupId":"BG001","lowerLimit":"1","upperLimit":"21","value":"10"},{"groupId":"BG002","lowerLimit":"1","upperLimit":"21","value":"9"}]}]}],"dispersionType":"FULL_RANGE","paramType":"MEDIAN","title":"Age, Continuous","unitOfMeasure":"Year"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"30"},{"groupId":"BG001","value":"29"},{"groupId":"BG002","value":"59"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"46"},{"groupId":"BG001","value":"41"},{"groupId":"BG002","value":"87"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":"American Indian or Alaska Native"},{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"3"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":"Native Hawaiian or Other Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"5"},{"groupId":"BG001","value":"6"},{"groupId":"BG002","value":"11"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"59"},{"groupId":"BG001","value":"51"},{"groupId":"BG002","value":"110"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"10"},{"groupId":"BG001","value":"12"},{"groupId":"BG002","value":"22"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"23"},{"groupId":"BG001","value":"16"},{"groupId":"BG002","value":"39"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"51"},{"groupId":"BG001","value":"53"},{"groupId":"BG002","value":"104"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"1"},{"groupId":"BG002","value":"3"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"71"},{"groupId":"BG001","value":"62"},{"groupId":"BG002","value":"133"}]}],"title":"United States"},{"categories":[{"measurements":[{"groupId":"BG000","value":"3"},{"groupId":"BG001","value":"2"},{"groupId":"BG002","value":"5"}]}],"title":"Canada"},{"categories":[{"measurements":[{"groupId":"BG000","value":"2"},{"groupId":"BG001","value":"6"},{"groupId":"BG002","value":"8"}]}],"title":"Australia"}],"paramType":"NUMBER","title":"Region of Enrollment","unitOfMeasure":"participants"}]}