{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.545798","value":"32.69931"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"58"}],"units":"Participants"}],"description":"Mean and standard deviation of peak plasma concentration. Specimen draws were performed only with dose 1, day 1 of induction II of AraC. First sample drawn pre-infusion, then drawn 30 mins prior to the end of the infusion, and then drawn for 6 time periods post infusion up to 8 hours post infusion (and before the 2nd dose of AraC). Results are based from these multiple time points on Day 1 of Induction II only.","dispersionType":"Standard Deviation","groups":[{"description":"INDUCTION THERAPY COURSE I: Patients receive cytarabine IT on day 1 and cytarabine IV continuously over 96 hours, daunorubicin hydrochloride IV continuously, and oral thioguanine BID on days 1-4.\n\nCOURSE II: Patients receive high-dose cytarabine IV over 3 hours BID on days 1, 2, 8, and 9 and asparaginase (IM) on days 2 and 9.\n\nCOURSE III: Patients receive treatment as in course I. COURSE IV: Patients receive cytarabine IV, daunorubicin hydrochloride IV, and oral thioguanine as in course I INTENSIFICATION THERAPY: Patients receive cytarabine IV continuously over 168 hours on days 1-7 and etoposide IV over 1 hour on days 1-3. Treatment repeats every 28 days for 2 courses in the absence of disease progression or unacceptable toxicity.\n\nasparaginase: Given IM daunorubicin hydrochloride: Given IV cytarabine: Given IV or IT thioguanine: Given orally etoposide: Given IV laboratory biomarker analysis: Correlative studies","id":"OG000","title":"Treatment (Combination Chemotherapy)"}],"paramType":"MEAN","populationDescription":"Ineligible patients (n=1) are excluded. Patients without available data from peak plasma concentration (n=146) are excluded.","reportingStatus":"POSTED","timeFrame":"Days 1, 2, 8, and 9 of induction II","title":"Cytarabine Drug Sensitivity by R-Strip (MicroMath) Curve Fitting Program","type":"SECONDARY","unitOfMeasure":"Mean micromolar"}