{"denoms":[{"counts":[{"groupId":"BG000","value":"205"}],"units":"Participants"}],"groups":[{"description":"INDUCTION THERAPY COURSE I: Patients receive cytarabine IT on day 1 and cytarabine IV continuously over 96 hours, daunorubicin hydrochloride IV continuously, and oral thioguanine BID on days 1-4. COURSE II: Patients receive high-dose cytarabine IV over 3 hours BID on days 1, 2, 8, and 9 and asparaginase (IM) on days 2 and 9.\n\nCOURSE III: Patients receive treatment as in course I. COURSE IV: Patients receive cytarabine IV, daunorubicin hydrochloride IV, and oral thioguanine as in course I\n\nINTENSIFICATION THERAPY: Patients receive cytarabine IV continuously over 168 hours on days 1-7 and etoposide IV over 1 hour on days 1-3. Treatment repeats every 28 days for 2 courses in the absence of disease progression or unacceptable toxicity.\n\nasparaginase: Given IM\n\ndaunorubicin hydrochloride: Given IV\n\ncytarabine: Given IV or IT\n\nthioguanine: Given orally\n\netoposide: Given IV\n\nlaboratory biomarker analysis: Correlative studies","id":"BG000","title":"Treatment (Combination Chemotherapy)"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"265.73","value":"616.41"}]}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","title":"Age, Continuous","unitOfMeasure":"days"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"205"}],"title":"<=18 years"},{"measurements":[{"groupId":"BG000","value":"0"}],"title":"Between 18 and 65 years"},{"measurements":[{"groupId":"BG000","value":"0"}],"title":">=65 years"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Age, Categorical","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"106"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"99"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"0"}],"title":"American Indian or Alaska Native"},{"measurements":[{"groupId":"BG000","value":"12"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"2"}],"title":"Native Hawaiian or Other Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"28"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"141"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"0"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"22"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"48"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"154"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"3"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"187"}]}],"title":"United States"},{"categories":[{"measurements":[{"groupId":"BG000","value":"11"}]}],"title":"Canada"},{"categories":[{"measurements":[{"groupId":"BG000","value":"7"}]}],"title":"Australia"}],"paramType":"NUMBER","title":"Region of Enrollment","unitOfMeasure":"participants"}]}