{"groups":[{"description":"Subjects will receive transplant conditioning with Ara-C, Cyclophosphamide, Campath-1H, Total Body Irradiation and will then receive T cell depleted stem cell infusion processed by the CLINIMACS Device\n\nAra-C: day-8 through day-5\n\n3 g/m2 q 12 hours\n\nCyclophosphamide: day-7 and day-6\n\n45 mg/kg\n\nCampath-1H: day-3 through day-1\n\nDosing for children:\n\n5 - 15kg : 3mg IV in 30ml NS\n\n15.1 - 30kg : 5mg IV in 50ml NS\n\n\\>30 kg : 10mg IV in 100ml NS\n\nAdults will receive 10mg IV in 100ml NS\n\nTotal Body Irradiation: day-4 through day-1\n\n175 cGy x 2 at 24 cGy/min\n\nStem Cell Infusion: Stem cells are infused on day 0","id":"FG000","title":"CLINIMACS Device"},{"description":"Subjects will receive transplant conditioning with Ara-C, Cyclophosphamide, Campath-1H, Total Body Irradiation and will then receive T cell depleted stem cell infusion processed by the ISOLEX Device\n\nAra-C: day-8 through day-5\n\n3 g/m2 q 12 hours\n\nCyclophosphamide: day-7 and day-6\n\n45 mg/kg\n\nCampath-1H: day-3 through day-1\n\nDosing for children:\n\n5 - 15kg : 3mg IV in 30ml NS\n\n15.1 - 30kg : 5mg IV in 50ml NS\n\n\\>30 kg : 10mg IV in 100ml NS\n\nAdults will receive 10mg IV in 100ml NS\n\nTotal Body Irradiation: day-4 through day-1\n\n175 cGy x 2 at 24 cGy/min\n\nStem Cell Infusion: Stem cells are infused on day 0","id":"FG001","title":"ISOLEX Device"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"1"},{"groupId":"FG001","numSubjects":"0"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"4"}],"type":"Death"},{"reasons":[{"groupId":"FG000","numSubjects":"6"},{"groupId":"FG001","numSubjects":"10"}],"type":"Relapse"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"3"}],"type":"Subsequent transplant"},{"reasons":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"0"}],"type":"Treatment - hematopoietic cell product"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"18"},{"groupId":"FG001","numSubjects":"28"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"7"},{"groupId":"FG001","numSubjects":"11"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"11"},{"groupId":"FG001","numSubjects":"17"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}]}