{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.158","value":"0.97"}]}],"title":"Cycle 1 / Week 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.159","value":"0.98"}]}],"title":"Cycle 1 / Week 1 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.158","value":"0.97"}]}],"title":"Cycle 1 / Week 3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.154","value":"0.97"}]}],"title":"Cycle 1 / Week 3 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.144","value":"0.95"}]}],"title":"Cycle 2 / Week 5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.148","value":"0.96"}]}],"title":"Cycle 2 / Week 5 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.140","value":"0.95"}]}],"title":"Cycle 2 / Week 7"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.146","value":"0.96"}]}],"title":"Cycle 2 / Week 7 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.147","value":"0.99"}]}],"title":"Cycle 3 / Week 9"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.121","value":"0.97"}]}],"title":"Cycle 3 / Week 9 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.142","value":"0.97"}]}],"title":"Cycle 3 / Week 11"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.104","value":"0.95"}]}],"title":"Cycle 3 / Week 11 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.152","value":"0.99"}]}],"title":"Cycle 4 / Week 13"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.111","value":"0.96"}]}],"title":"Cycle 4 / Week 13 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.154","value":"0.99"}]}],"title":"Cycle 4 / Week 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.111","value":"0.96"}]}],"title":"Cycle 4 / Week 15 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.151","value":"0.98"}]}],"title":"Cycle 5 / Week 17"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.110","value":"0.96"}]}],"title":"Cycle 5 / Week 17 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.157","value":"1.00"}]}],"title":"Cycle 5 / Week 19"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.111","value":"0.97"}]}],"title":"Cycle 5 / Week 19 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.162","value":"1.01"}]}],"title":"Cycle 6 / Week 21"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.114","value":"0.98"}]}],"title":"Cycle 6 / Week 21 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.169","value":"1.01"}]}],"title":"Cycle 6 / Week 23"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.115","value":"0.99"}]}],"title":"Cycle 6 / Week 23 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.154","value":"1.11"}]}],"title":"Cycle 7 / Week 25"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.148","value":"1.03"}]}],"title":"Cycle 7 / Week 25 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.198","value":"1.08"}]}],"title":"Cycle 7 / Week 27"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.148","value":"1.03"}]}],"title":"Cycle 7 / Week 27 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.213","value":"1.05"}]}],"title":"Cycle 8 / Week 29"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.140","value":"0.99"}]}],"title":"Cycle 8 / Week 29 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.213","value":"1.05"}]}],"title":"Cycle 8 / Week 31"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.085","value":"1.04"}]}],"title":"Cycle 8 / Week 31 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.488","value":"1.10"}]}],"title":"Cycle 9 / Week 33"},{"categories":[{"measurements":[{"comment":"Only 1 patient was dosed.","groupId":"OG000","spread":"NA","value":"0.75"}]}],"title":"Cycle 9 / Week 33 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.417","value":"1.15"}]}],"title":"Cycle 9 / Week 35"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.311","value":"1.22"}]}],"title":"Cycle 10 / Week 37"},{"categories":[{"measurements":[{"comment":"Only 1 patient was dosed.","groupId":"OG000","spread":"NA","value":"1.00"}]}],"title":"Cycle 10 / Week 37 Day 4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.311","value":"1.22"}]}],"title":"Cycle 10 / Week 39"},{"categories":[{"measurements":[{"comment":"Only 1 patient was dosed.","groupId":"OG000","spread":"NA","value":"1.00"}]}],"title":"Cycle 10 / Week 39 Day 18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.311","value":"1.22"}]}],"title":"Cycle 11 / Week 41"},{"categories":[{"measurements":[{"comment":"Only 1 patient was dosed.","groupId":"OG000","spread":"NA","value":"1.00"}]}],"title":"Cycle 11 / Week 41 Day 4"},{"categories":[{"measurements":[{"comment":"Only 1 patient was dosed.","groupId":"OG000","spread":"NA","value":"1.44"}]}],"title":"Cycle 11 / Week 43"},{"categories":[{"measurements":[{"comment":"Only 1 patient was dosed.","groupId":"OG000","spread":"NA","value":"1.00"}]}],"title":"Cycle 11 / Week 43 Day 18"}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"}],"units":"Participants"}],"description":"Relative dose intensity is defined as actual dose/scheduled dose. Bortezomib is administered on Days 1, 4, 15, and 18 every 28 days.","dispersionType":"Standard Deviation","groups":[{"description":"All subjects received bortezomib 1.3mg/m\\^2 on Days 1, 4, 15, and 18 every 28 days and dexamethasone 20mg daily on Days 1, 2, 4, 5, 15, 16, 18, and 19 every 28 days. Following US FDA approval of doxorubicin HCl liposome injection in combination with bortezomib in May 2007, the study was amended to allow combination treatment with both bortezomib and doxorubicin HCl liposome injection 30 mg/m\\^2 on Day 4 every 28 days with dexamethasone. The target goal was 8 cycles of treatment.","id":"OG000","title":"Treatment Group"}],"paramType":"MEAN","populationDescription":"Note that the sample sized varied at each dose and ranged from 32 patients to 1 patient.","reportingStatus":"POSTED","timeFrame":"Each dose of bortezomib (days 1, 4, 15, and 18 every 28 days)","title":"Relative Dose Intensity of Bortezomib","type":"SECONDARY","unitOfMeasure":"Relative dose intensity"}