{"analyses":[{"ciLowerLimit":"0.76","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.88","groupDescription":"Kappa statistic and its 95% confidence interval are used to assess agreement beyond random.","groupIds":["OG000","OG001","OG002"],"nonInferiorityType":"OTHER","paramType":"Kappa statistic","paramValue":"0.82"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"38"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"1"}]}],"title":"Histologic grade 1 by central pathology reviewers"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"56"},{"groupId":"OG002","value":"9"}]}],"title":"Histologic grade 2 by central pathology reviewers"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"10"},{"groupId":"OG002","value":"268"}]}],"title":"Histologic grade 3 by central pathology reviewers"}],"denoms":[{"counts":[{"groupId":"OG000","value":"45"},{"groupId":"OG001","value":"71"},{"groupId":"OG002","value":"278"}],"units":"Participants"}],"description":"Histologic grades were determined by the central pathology reviewers and institutional pathologists based on published standards. A higher grade is associated with a more severe disease.","groups":[{"id":"OG000","title":"Histologic Grade 1 by Enrolling Institution"},{"id":"OG001","title":"Histologic Grade 2 by Enrolling Institution"},{"id":"OG002","title":"Histologic Grade 3 by Enrolling Institution"}],"paramType":"NUMBER","populationDescription":"Ineligible patients, as well as patients without histologic grade determined by enrolling institution or central pathology reviewers were excluded. The OM evaluates the degree of agreement of two pathology grading reviews at diagnosis. The time frame \"At diagnosis\" reflects the OM.","reportingStatus":"POSTED","timeFrame":"At Diagnosis","title":"Degree of Agreement in Histologic Grade Determined by the Enrolling Institution Versus by Central Pathology Reviewers","type":"SECONDARY","unitOfMeasure":"Participants"}