{"description":"Adverse experiences as coded using CTC AE version 4 were collected only for patients who received chemotherapy according to protocol guidelines. Of the 105 eligible patients with high risk features, ninety-three (93) were given protocol chemotherapy based on the assessment of the central pathology review, as described in section 4 of the ARET0332 protocol.","eventGroups":[{"deathsNumAffected":0,"deathsNumAtRisk":93,"description":"Includes patients who may or may not require chemotherapy. Patients who require chemotherapy receive vincristine IV and carboplatin IV over 1 hour on day 1 and etoposide IV over 1 hour on days 1 and 2. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity and patients who complete chemotherapy are followed after completion of therapy periodically for at least 5 years. Patients who do not require chemotherapy undergo observation periodically for at least 5 years.","id":"EG000","otherNumAffected":19,"otherNumAtRisk":93,"seriousNumAffected":0,"seriousNumAtRisk":93,"title":"Group 1 (Identified by Central Review as High Risk)"},{"deathsNumAffected":0,"deathsNumAtRisk":0,"description":"Patients undergo observation periodically for at least 5 years.","id":"EG001","otherNumAffected":0,"otherNumAtRisk":0,"seriousNumAffected":0,"seriousNumAtRisk":0,"title":"Group 2 (Identified by Central Review as Not High Risk)"}],"frequencyThreshold":"0","otherEvents":[{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Alanine aminotransferase increased"},{"organSystem":"Immune system disorders","stats":[{"groupId":"EG000","numAffected":5,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Anaphylaxis"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Anemia"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Anorexia"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Aspartate aminotransferase increased"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Constipation"},{"organSystem":"Metabolism and nutrition disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Dehydration"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Diarrhea"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Enterocolitis infectious"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Eye infection"},{"organSystem":"Blood and lymphatic system disorders","stats":[{"groupId":"EG000","numAffected":9,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Febrile neutropenia"},{"organSystem":"Nervous system disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Headache"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Infections and infestations - Other, specify"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":6,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Neutrophil count decreased"},{"organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Otitis media"},{"organSystem":"Investigations","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Platelet count decreased"},{"organSystem":"Skin and subcutaneous tissue disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Rash maculo-papular"},{"organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":93},{"groupId":"EG001","numAffected":0,"numAtRisk":0}],"term":"Vomiting"}]}