{"groups":[{"description":"Zoledronic acid 4 mg by intravenous injection with a subcutaneous denosumab placebo once every 4 weeks","id":"FG000","title":"Zoledronic Acid"},{"description":"Denosumab 120 mg subcutaneously with an intravenous zoledronic acid placebo once every 4 weeks","id":"FG001","title":"Denosumab"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"269"},{"groupId":"FG001","numSubjects":"294"}],"type":"Death"},{"reasons":[{"groupId":"FG000","numSubjects":"164"},{"groupId":"FG001","numSubjects":"147"}],"type":"Withdrawal by Subject"},{"reasons":[{"groupId":"FG000","numSubjects":"113"},{"groupId":"FG001","numSubjects":"117"}],"type":"Disease progression"},{"reasons":[{"groupId":"FG000","numSubjects":"43"},{"groupId":"FG001","numSubjects":"56"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"13"},{"groupId":"FG001","numSubjects":"9"}],"type":"Lost to Follow-up"},{"reasons":[{"groupId":"FG000","numSubjects":"4"},{"groupId":"FG001","numSubjects":"1"}],"type":"Physician Decision"},{"reasons":[{"groupId":"FG000","numSubjects":"14"},{"groupId":"FG001","numSubjects":"7"}],"type":"Noncompliance"},{"reasons":[{"groupId":"FG000","numSubjects":"4"},{"groupId":"FG001","numSubjects":"3"}],"type":"Protocol deviation"},{"reasons":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"3"}],"type":"Ineligibility determined"},{"reasons":[{"groupId":"FG000","numSubjects":"75"},{"groupId":"FG001","numSubjects":"52"}],"type":"Participant request"},{"reasons":[{"groupId":"FG000","numSubjects":"42"},{"groupId":"FG001","numSubjects":"33"}],"type":"Other"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"951"},{"groupId":"FG001","numSubjects":"950"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"946"},{"groupId":"FG001","numSubjects":"942"}],"type":"Received Investigational Product"},{"achievements":[{"groupId":"FG000","numSubjects":"208"},{"groupId":"FG001","numSubjects":"228"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"743"},{"groupId":"FG001","numSubjects":"722"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}],"preAssignmentDetails":"1904 participants were enrolled, however 3 were excluded from all analyses as Institutional Review Board review activities and oversight were not ensured.","recruitmentDetails":"Participants were enrolled from 12 May 2006 through 18 December 2008."}