{"groups":[{"description":"Zoledronic acid 4 mg by intravenous injection with subcutaneous denosumab placebo once every 4 weeks","id":"FG000","title":"Zoledronic Acid"},{"description":"Denomsumab 120 mg subcutaneously with intravenous zoledronic acid placebo once every 4 weeks","id":"FG001","title":"Denosumab"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"169"},{"groupId":"FG001","numSubjects":"174"}],"type":"Death"},{"reasons":[{"groupId":"FG000","numSubjects":"124"},{"groupId":"FG001","numSubjects":"124"}],"type":"Disease progression"},{"reasons":[{"groupId":"FG000","numSubjects":"117"},{"groupId":"FG001","numSubjects":"118"}],"type":"Withdrawal by Subject"},{"reasons":[{"groupId":"FG000","numSubjects":"57"},{"groupId":"FG001","numSubjects":"61"}],"type":"Participant request"},{"reasons":[{"groupId":"FG000","numSubjects":"43"},{"groupId":"FG001","numSubjects":"28"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"15"},{"groupId":"FG001","numSubjects":"14"}],"type":"Physician Decision"},{"reasons":[{"groupId":"FG000","numSubjects":"4"},{"groupId":"FG001","numSubjects":"10"}],"type":"Noncompliance"},{"reasons":[{"groupId":"FG000","numSubjects":"7"},{"groupId":"FG001","numSubjects":"8"}],"type":"Lost to Follow-up"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"2"}],"type":"Protocol deviation"},{"reasons":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"1"}],"type":"Ineligibility determined"},{"reasons":[{"groupId":"FG000","numSubjects":"21"},{"groupId":"FG001","numSubjects":"18"}],"type":"Other"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"1020"},{"groupId":"FG001","numSubjects":"1026"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"1014"},{"groupId":"FG001","numSubjects":"1019"}],"type":"Received Investigational Product"},{"achievements":[{"groupId":"FG000","numSubjects":"461"},{"groupId":"FG001","numSubjects":"468"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"559"},{"groupId":"FG001","numSubjects":"558"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}],"preAssignmentDetails":"2049 patients were enrolled in the study, but 3 patients were excluded from all analyses because properly documented informed consent was not obtained.","recruitmentDetails":"Participants were enrolled from 27 April 2006 through 31 December 2007"}