{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.4","value":"85.6"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"}],"units":"Participants"}],"description":"Clearance (CL) can be defined as the volume of plasma which is completely cleared of drug (pemetrexed) per unit time. Total body clearance is calculated after intravenous administration of the drug (pemetrexed) and is measured by taking plasma samples at various timepoints and measuring the amount of pemetrexed in the plasma.","dispersionType":"Standard Deviation","groups":[{"description":"Pemetrexed 500 mg/m2 intravenous (IV) every 21 days for 6 cycles","id":"OG000","title":"Pemetrexed"}],"paramType":"MEAN","populationDescription":"Patients who received at least one dose of study drug.","reportingStatus":"POSTED","timeFrame":"Cycle 1 and Cycle 2: before the end of infusion (approximately 9.5 minutes), 2 hours, 9-10 hours, 24-48 hours, 480-528 hours (20 to 22 days) after start of pemetrexed infusion","title":"Pemetrexed Population Pharmacokinetics (PK): Clearance","type":"SECONDARY","unitOfMeasure":"milliliter per minute (mL/min)"}